妇幼保健院内乳腺科CA-MRSA感染危险因素分析及耐药基因检测

Analysis of Risk Factors of CA-MRSA Infection and Detection of Drug Resistance Genes in Department of Internal Medicine of Maternal and Child Health Care Hospital

目的:分析妇幼保健院内获得性耐甲氧西林金黄色葡萄球菌(CA-MRSA)感染危险因素及耐药基因检测情况。方法:将2014年1月-2016年7月妇幼保健院内CA-MRSA感染的乳腺癌患者560例作为研究对象,分析导致CA-MRSA感染的危险因素,使用聚合酶连反应方法(Polymerase-Chain Reaction,PCR)检测耐药基因。结果:多因素非条件Logistic回归分析显示,基础疾病严重、侵入性操作及长期使用抗菌药物是导致CA-MRSA感染的危险因素(P<0.05)。结论:基础疾病严重、侵入性操作及长期使用抗菌药物是导致CA-MRSA感染的危险因素,CA-MRSA呈多重耐药性。

Objective： To analyze the risk factors of CA-MRSA infection and the detection of drug resistance genes in Maternal and Child Health Care Hospital.Method： 560 CA-MRSA infection in breast cancer patients in Maternal and Child Health Care Hospital from January 2014 to July 2016 were selected as objects, the risk factors of CA-MRSA infection were analyzed, and the drug resistance genes were detected by polymerase chain reaction.Result： Muhivariate non conditional Logistic regression analysis showed that severe underlying diseases, invasive procedures, and long-term use of antibiotics were risk factors for CA-MRSA infection （ P〈0.05 ）. Conclusion： The underlying disease is serious, invasive operation and long-term use of antibiotics is a risk factor for CA-MRSA infection, CA-MRSA showed multiple drug resistance.