脐血维生素D水平与婴幼儿一年内喘息发作的关系

Association between cord blood 25-hydroxyvitamin D concentrations and infantile wheezing during the first year

目的研究脐血维生素D水平与婴幼儿生后一年内喘息发作的关系。方法采用酶联免疫法测定185名新生儿脐血25-羟维生素D[25(OH)D]浓度;采用问卷调查形式收集孕妇的健康状况及新生儿出生史;跟踪随访新生儿一年,了解其在随访期限喘息发作情况。结果新生儿脐血25(OH)D平均浓度为49.63±16.56nmol/L;随访期内,共有51名婴儿有喘息发作;采用多因素logistic回归分析表明,出生脐血25(OH)D<25nmol/L的婴儿较脐血25(OH)D>75nmol/L的婴儿其生后一年内发生喘息的风险性增高(OR=2.751,95%CI 1.430-66.5,P=0.024)。结论脐血25(OH)D水平与婴儿生后一年内的喘息发作呈负相关。

Objective To investigate the association between cord serum 25 （OH） D levels and wheezing in infants from birth to 1 year old. Methods Serum 25 （OH）D levels were measured by ELISA in cord blood of 185 newborns. The heahh status of pregnant women and history of newborn birth were recorded by questionnaires. The status of offspring wheezing were evaluated at approximately 1 year. Results The average value of 25 （OH） D was 49. 63±16. 56nmol/L. During follow-up, 51 infants experienced wheezing. By using muhivariable-adjusted logistic regression models, 25 （OH）D in cord blood below 25nmol/L increased the risk of wheezing during the first 1 year, comparing with25（OH）D above75nmol/L （0R=2.751, 95% CI1.430-66.5, P=0.024）. Conclusion Low cord serum 25 （OH） D levels show an association with an increased risk of infantile wheezing during the first 1 year