血清脂蛋白相关磷脂酶A2与急性冠脉综合征危险分层的相关性研究

Correlation Study of Serum Lipoprotein Associated Phospholipase A2 and Risk Stratification of Acute Coronary Syndrome

目的探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)与急性冠脉综合征(ACS)危险分层GRACE积分之间的相关性。方法选择2012年11月至2016年6月我科住院确诊ACS患者203例,患者根据GRACE积分被分为低危组(83例)、中危组(31例)、高危组(124例),并检测血清Lp-PLA2水平,分析血清Lp-PLA2水平与危险分层GRACE积分之间的关系。结果血清Lp-PLA2水平在低危组为(171.31±58.31)ng/mL、中危组为(258.42±78.94)ng/mL、高危组为(309.84±91.73)ng/mL,三组比较差异有统计学意义(P<0.05);线性回归分析提示ACS患者血清Lp-PLA2水平与GRACE积分呈正相关(r=0.791,P<0.01)。结论血清Lp-PLA2水平对于早期评价ACS患者风险程度具有一定的临床意义。

Objective To investigate the correlation between serum lipoprotein associated phospholipase A2（ Lp-PLA2）and GRACE scoring,risk stratification of acute coronary syndrome（ ACS）. Methods 203 cases of confirmed ACS patients hospitalized between November 2012 and June 2016 in our department were included and divided into low-risk group（ 83 cases）,medium-risk group（ 31 cases） and high-risk group（ 124 cases） according to GRACE scoring. Serum Lp-PLA2 level was determined and relationship between serum Lp-PLA2 level and GRACE scoring was analyzed. Results Serum Lp-PLA2 level in low-risk group was（ 171. 31 ± 58. 31） ng/mL,in medium-risk group was（ 258. 42 ±78. 94） ng/mL and in high-risk group was（ 309. 84 ± 91. 73）ng/mL. Comparing the Lp-PLA2 level of the three groups,there were statistically significant differencesamong the three groups（ P〈0. 05）. Linear regression analysis indicated a positive correlation between serum Lp-PLA2 level and GRACE scoring in ACS patients（ r = 0. 791,P〈0. 01）. Conclusion Serum Lp-PLA2 level has certain clinical significance for the early evaluation of risk degree of ACS patients.