心型脂肪酸结合蛋白在急性心肌梗死早期诊断中的价值

Values of heart-type fatty acid-binding protein in early detection of acute myocardial infraction

目的:探究血清心型脂肪酸结合蛋白在急性心肌梗死早期诊断中的临床价值。方法:选取临床诊断为急性心肌梗死的患者50例作为病例组,按照发病时间将50例患者分为0.5 h~组(22例)和3~6 h组(28例)。另选取同期就诊且诊断为慢性心肌损伤的患者30例,肌肉损伤患者20例;50例健康体检者作为对照组。测定血清H-FABP、CK-MB、c Tn I和MYO的浓度。结果:(1)0.5 h~组和3~6 h组患者血清H-FABP、CK-MB、c Tn I和MYO浓度均高于对照组(P<0.01);(2)肌肉损伤患者血清MYO浓度高于对照组(P<0.01);(3)0.5 h~组H-FABP的阳性率高于MYO(P<0.05)和CK-MB(P<0.01)。结论:HFABP可作为AMI早期诊断中一种良好的血清标志物。

Objective： To assess the values of heart-type fatty acid-binding protein（H-FABP） in the early diagnosis of acute myocardial infarction（AMI）.Methods： Fifty patients of clinically confirmed AMI were included as experimental group that were subgrouped into 0.5 h-group（n=22） and 3-6 h group（n=28）by time since onset of chest pain.Thirty patients diagnosed as chronic myocardial injury,20 with muscle injury,and 50 subjects undergoing health examination in the corresponding period were recruited as controls.All participants were subjected to measurement of serum H-FABP,creatine kinase MB（CK-MB）,cardiac troponin Ⅰ（cTnⅠ） and myoglobin（MYO） concentrations.Results：①Patients in the 0.5 h-group and 3-6 h group had higher serum H-FABP,CK-MB,cTnI and MYO concentrations than the controls（P〈0.01）;②Patients with muscle injury had higher serum MYO levels than the controls（P〈0.01）;③The positive rate for H-FABP was higher than that for MYO（P〈0.05） and CK-MB（P〈0.01） in 0.5 h-group.Conclusion：H-FABP can be used as a better biomarker for early diagnosis of AMI.