成釉细胞癌诊治及文献复习

Diagnosis and treatment of ameloblastic carcinoma: Report of 3 cases with literature review

目的:了解成釉细胞癌的发病年龄、性别、好发部位、区域等临床特征和治疗效果。方法:分析我院3例成釉细胞癌和近5年与其相关文献的临床资料。结果:54例病例发病年龄14~86岁,中位数为50.5岁,男女比为3.15∶1,上下颌骨发病率为1∶2,治疗方式以手术为主,术后辅以放化疗。结论:成釉细胞癌是一种罕见的牙源性上皮性恶性肿瘤,以中老年人多见,男性多于女性,下颌骨多于上颌骨,发病存在区域性,其侵袭性强,预后一般,临床常采用以手术为主的综合性治疗,术后需长期随访。

Objective：To understand the ages, genders, predilection site and regions, clinical pictures and curative effects of ameloblastic carcinoma.Methods： Clinical data were retrospectively examined in 3 cases of ameloblastic carcinoma, and related literatures published in the past five years were reviewed.Results： Of the 54 cases included in the related literatures, the age at onset ranged from 14 to 86 years, with a mean age of 50.5 years.Male to female ratio was 3.15 to 1.Predilection site was involved in maxillary and mandible, with a ratio of 1∶2.Treatment options primarily included surgery and postoperative adjunct chemo-and radio-therapy.Conclusion： Ameloblastic carcinoma is a rare malignant epithelial odontogenic tumor, seen in middle and older ages and affecting more men than women.The lesion is regional and maxillary and mandible are mostly involved.This tumor is more aggressive, and its prognosis is poor.Treatment of such tumor primarily relies on surgery based on coordinated efforts of team of medical professionals, and patients require long-term post-operative follow-up.