INTRABEAM放疗系统在乳腺癌保乳术中应用研究

INTRABEAM intraoperative radiotherapy in breast conserving surgery for early breast cancer

目的研究INTRABEAM放疗系统在乳腺癌保乳术中应用的安全性和可行性。方法选择2013年1月到2014年12月符合入组条件在济南军区总医院甲状腺乳腺外科行INTRABEAM术中放疗保乳手术的乳腺癌患者。所有患者均行保乳手术联合INTRABEAM术中照射20 Gy，记录术后切口及急性放射性损伤发生率。随访评估患者乳房恢复情况及美容效果、早期总生存率、无复发生存率和无转移生存率。结果所有患者均行保乳联合INTRABEAM术中放疗，术中照射20 Gy，中位时间为31（25~39）min，5例追加术后全乳外照射。术后1例发生切口感染，5例出现术后积液，4例出现放射区皮肤疼痛，2周后自行缓解。短期随访所有患者患侧乳房满意度优良率为93.0%,总生存率、无复发生存率和无转移生存率均为100%。 结论对早期乳腺癌患者行保乳手术联合INTRABEAM术中放疗是安全可行的。

ObjectiveTo evaluate the safety and feasibility of INTRABEAM in breast conserving surgery for early stage breast cancer.MethodsClinical data of 43 cases of early breast cancer undergoing INTRABEAM intraopetative radiotherapy from Jan. 2013 to Dec. 2014 were retrospectively analyzed. All cases underwent breast conserving surgery combined with 20 Gy INTRABEAM intraoperative radiotherapy. The postoperative incision, incidence of local complications and acute radiation injury were recorded after surgery. Breast recovery, the cosmetic effects, early overall survival, recurrence-free survival, and non-metastatic survival were followed up.ResultsAll cases were given breast conserving surgery associated with INTRABEAM intraoperative radiotherapy （20 Gy） , with median radiotherapy time of 31 mins ranging from 25 to 39 mins. Five cases underwent postoperative whole breast irradiation. Major early complications included incision infection （1 case） , postoperative effusion （5 cases） , radiation area skin pain （4 cases） . The short-term follow-up survey showed that the satisfaction rate was 93.0%. The overall survival rate, recurrence free survival rate and metastasis free survival rate was 100% respectively.ConclusionBreast conseving surgery combined with INTRABEAM intraoperative radiotherapy for early breast cancer patients is safe and feasible.