A型肉毒毒素注射美容不良反应的评估及诊治

Diagnosis and management of adverse reaction due to botulinum toxin type A

目的 评估局部注射A型肉毒毒素美容不良反应的临床表现及抗毒素治疗效果.方法 回顾性分析40例A型肉毒毒素注射美容后引起不良反应的诊治过程.根据患者临床表现和神经系统检查评估患者不良反应严重程度,并分别给予对症处理、观察处理或肉毒抗毒素治疗.结果 40例不良反应主要为神经系统异常,其中4例（10％）出现呼吸困难.36例（90％）仅给予对症处理,4例（10％）给予肉毒抗毒素治疗,分别随访1～3个月,患者完全恢复正常,均未留有任何神经系统后遗症状.结论 注射A型肉毒毒素美容,一旦发生中毒,尽早给予肉毒抗毒素治疗.

Objective To analyze the clinical manifestation caused by local injections of botulinum toxin type A for cosmetic reason and the effect of antitoxin for adverse reaction.Methods Diagnosis and treatment process of 40 patients were retrospectively analyzed for adverse reactions due to botulinum toxin injections for beauty.Severe adverse reaction was assessed according to the patients clinical manifestation and the nervous system of physical assessment.The patients were given symptomatic treatment,observation or antitoxin therapy.Results Adverse reactions developed in 40 patients were mainly the nervous system abnormalities.Dyspnea developed in four cases.34 cases （85 %） were given symptomatic treatment.4 cases （10 %） were given botox treatment,and the patients were followed up for 1-3 months.The patients fully recovered to normal and did not leave any neurological sequelae.Conclusions The management of type A botulinum toxin injections should be strengthened.In case of poisoning,antitoxin therapy should be given as early as possible.