中药人参皂苷联合大剂量干扰素在皮肤恶性黑色素瘤术后辅助治疗中的应用

Clinical application of Chinese medicine combined with high dose interferon in postoperative adjuvant therapy of malignant melanoma of the skin

目的 探讨中药人参皂苷联合大剂量干扰素在皮肤恶性黑色素瘤术后辅助治疗中的应用价值.方法 对20例皮肤恶性黑色瘤术后患者使用大剂量干扰素α-2b（甘乐能）1800万IU皮下注射,每周连续5d,4周1个疗程,随后改为900万IU,每周3次,共12个月,联合中药人参皂苷（0.25 g,饭前1h口服,每天2次,每月服用3周,用药12个月）辅助治疗.结果 20例患者中仅有1例死亡,治疗过程中发现局部以及远处转移的病灶均消失.结论 中药人参皂苷联合大剂量干扰素在皮肤恶性黑色素瘤术后辅助治疗中起到重要的作用.

Objective To study the effect of Chinese medicine combined with large dose interferon in the postoperative adjuvant therapy of malignant melanoma of the skin.Methods A high dose of interferon alpha-2b （GanLeneng） （1200 IU/per day） was used in 20 cases of malignant melanoma of skin for 7 days.One course of treatment was 3 months,8 consecutive courses of treatment and traditional Chinese medicine （0.25 g） were administered 1 hour before meals,2 times a day,taking three weeks per month.Results One patient in 20 cases of patients did not receive timely treatment and resulted in death.The remaining patients were were still live from 2012 to the present.Local and distant metastasis lesions disappeared during the course of treatment.Conclusions Traditional Chinese medicine combined with high-dose interferon in cutaneous malignant melanoma as adjuvant treatment plays an important role.