摘要
目的:优选运脾通便合剂提取工艺。方法:以浸膏得率以及橙皮苷、白术内酯Ⅲ含量的综合评分为指标,在单因素试验基础上,选择提取时间、提取次数和液料比为自变量,采用Box-Benhnken响应面分析法优选最佳提取工艺。结果:运脾通便合剂最佳提取工艺条件为:提取3次、15倍溶剂、提取66min。此条件下综合评分预测值为1.20478,实测值为1.19840。结论:优选的提取工艺简便可行,预测性良好。
Objective： To optimize the extraction process of Yunpitongbian decoction. Methods： With the extraction yield and the contents of hesperidin and atractylenolide III as the comprehensive evaluation indices, and based on the resuhs of single factor tests, Box-Behnken response surface methodology was used to optimize the extraction process with the extraction duration, extraction times and liquid-solid ratio as the independent variables. Results： The optimum processing conditions were as follows, extracted three times with 15-fold amount of solvent and extraction time of 66 min. The measured value of comprehensive score was 1. 198 40, which was close to the predicted value of 1. 204 78. Conclusion： The optimized extraction process of Yunpitongbian decoction is simple and feasible with good predictability.
出处
《中国药师》
CAS
2017年第5期777-780,共4页
China Pharmacist
基金
国家自然科学基金青年科学基金项目(编号:81603310)
南京中医药大学附属医院江苏省中医院2016院级课题(编号:Y16022)
关键词
运脾通便合剂
橙皮苷
白术内酯Ⅲ
响应面法
Yunpitongbian decoction
Hesperidin
Atractylenolide III
Response surface methodology
