藏药川木香的化学成分研究

Chemical Constituents in Tibetan Medicine Dolomiaea Souliei(Franch.) Shih

目的:研究藏药川木香根的化学成分。方法:采用多种柱色谱方法对藏药川木香根的化学成分进行分离,通过波谱分析和文献对比鉴定化合物结构。结果:分离得到6个化合物,包括3个倍半萜类化合物、3个脂肪酸类化合物,分别鉴定为二氢去氢木香内酯(Ⅰ)、vladimenal(Ⅱ)、矮艾素A(Ⅲ)、正十一烷(Ⅳ)、琥珀酸(Ⅴ)、亚油酸甲酯(Ⅵ)。结论:化合物Ⅳ~Ⅵ均为首次从该属植物中分离得到。

Objective： To study the chemical constituents in the dry roots of Dolomiaea souliei （ Franch. ） Shih. Methods： Vari- ous chromatographic methods were used to isolate and purify the chemical constituents of Dolomiaea souliei, and the structures were elucidated through the analysis of spectral data and literatures. Results： Six compounds including 3 sesquiterpene compounds and 3 fatty acids were obtained and identified as dihydrodehydrocostuslactone（ I ）, vladimenal（ II ）, arbusculin A（ III ）, n-hendecane（IV）, bu- tanedioic acid （ V ） and methyl linoleate （ VI ）. Conclusion： Compounds IV - VI are obtained from the genus of Dolomiaea for the first