161例乳腺癌患者术后化疗依从性及影响因素分析

Postoperative chemotherapy compliance and influencing factors in 161 patients with breast cancer

目的探讨乳腺癌患者术后化疗依从性及其影响因素,为规范患者的治疗提供实证帮助。方法对2013年5月至2015年12月泰山医学院附属医院收治的行辅助化疗的161例乳腺癌术后患者进行横断面调查,包括基本情况及可能影响患者化疗依从性的主客观因素,对所得资料进行Logistic回归分析。结果乳腺癌患者整体化疗依从性较好,对不同年龄、文化程度、付费方式、化疗耐受性、家庭关系、术后康复训练患者的化疗依从性进行比较,差异均有统计学意义(均P<0.05);对婚姻状况进行比较,差异无统计学意义(P>0.05)。结论付费方式、文化程度、年龄、化疗耐受性、家庭关系、术后康复训练等影响化疗依从性的主要因素对患者依从性贡献程度依次减低。医务人员应详细了解患者病情资料,分析并制定化疗方案,做到精准化及规范化治疗,以提高患者术后化疗依从性,延长患者生存时间。

Objective To explore the chemotherapy compliance in patients with breast cancer after operation and its influencing factors,and to provide empirical evidence for the treatment of breast cancer. Methods A cross sectional study of 161 patients with breast cancer treated with adjuvant chemotherapy from May 2013 to December 2015 was carried out including the basic condition and possible subjective and objective factors which may affect the compliance with chemotherapy. The available data was analyzed by Logistic regression. Results In general,compliance with chemotherapy was good in patients with breast cancer. There was statistically significant difference in the compliance with chemotherapy among patients with different age,culture level,payment method,chemotherapy tolerance,family ties and postoperative rehabilitation training（ all P〈0. 05）; There was no statistically significant difference in the compliance with chemotherapy among patients with different marital status（ P〉0. 05）. Conclusion The influence of payment method,cultural degree,age,chemotherapy tolerance,family ties and postoperative rehabilitation training on compliance with chemotherapy gradually reduced. Clinicians should have a detailed understanding of patient＇s information when deciding a chemotherapy regimen, so as to achieve accurate and standardized treatment, improve compliance with chemotherapy,and prolong the survival time.