双歧杆菌三联活菌胶囊辅助治疗对新诊断2型糖尿病患者β细胞功能及胰岛素抵抗的影响

Influence of Bifid-Triple Viable capsules as adjuvant therapy on β cell function and insulin-resistance in patients with newly-diagnosed type 2 diabetes mellitus

目的探讨双歧杆菌三联活菌胶囊辅助治疗对新诊断2型糖尿病(T2DM)患者β细胞功能及胰岛素抵抗的影响。方法选取128例新诊断T2DM患者,随机分为研究组和对照组。两组患者均按照相同要求进行饮食控制和运动干预。对照组患者予以阿卡波糖联合甘精胰岛素控制血糖治疗;研究组患者在对照组治疗基础上加用双歧杆菌三联活菌胶囊420mg/次,3次/d,温水口服,两组患者均连用12周。观察并比较两组患者治疗前和治疗12周后糖代谢指标、β细胞功能及胰岛素抵抗的变化。结果治疗12周后,两组患者空腹血糖(FBG)、餐后2h血糖(2hPG)和糖化血红蛋白(HbA1C)较前明显下降(P<0.05或P<0.01),且研究组下降值较对照组更明显(P<0.05);同时两组患者HOMA-β较前明显上升,HOMA-IR较前明显下降,且研究组上升或下降值较对照组更明显(P<0.05)。结论双歧杆菌三联活菌胶囊辅助治疗新诊断T2DM患者可改善其β细胞功能,缓解胰岛素抵抗,提高胰岛素敏感性,从而改善糖代谢功能,有利于血糖稳定,使糖化血红蛋白达标。

Abstract： Objective To explore the influence of Bifid-Triple Viable capsules as adjuvant therapy （AT） on 13 cell function and insulin-resistance in patients with newly-diagnosed type 2 diabetes mellitus （T2DM） . Methods 128 patients newly diagnosed as T2DM were divided randomly into Research group or Control group, and given the same diet control and exercise intervention, as well as acarbose combined with insulin glargine to control blood sugar, while the patients in research group were additionally given 420 mg Bifid- Triple Viable capsules t. i.d. The treatment course was 12 weeks for both groups. The changes of glucose metabolism indexes, cell function and insulin resistance were observed and compared between the two groups before and after the treatment： Results After treatment, the levels of FBG, 2 hPG and HbA1C of patients were obviously declined （P〈0. 05 or P〈0.01）, with the declining rates in research group much higher than in control group （P〈0.05） . Meanwhile, the HOMA-β of patients in two groups obviously rose, while the HOMA-IR obviously declined, with the rising or declining rates in research group much higher than those in control group （P〈0.05） . Conclusion Bifid-Triple Viable capsules as AT can improve cell function, relieve insulin resistance, and raise insulin sensibility of patients with newly-diagnosed T2DM, thus improve lucose metabolism function, help to maintain glucostasis and normal glycosylated hemoglobin.