保妇康栓联合LEEP锥切术治疗宫颈上皮内瘤变伴高危型HPV感染的疗效观察

Baofukang suppository combined with LEEP for treatment of cervical intraepithelial neoplasia with high-risk HPV infection:Efficacy observation

目的探讨保妇康栓联合LEEP锥切术治疗宫颈上皮内瘤变(CIN)伴高危型HPV感染的临床疗效。方法选取2015年1月至2016年1月收治的CIN合并HPV感染患者120例,按照随机数字法分为观察组和对照组,每组60例,对照组给予LEEP术进行治疗,观察组在对照组基础上于术后给予保妇康栓进行治疗,观察并比较两组患者阴道出血量及出血时间、阴道排液量及时间、宫颈创面愈合时间,并对术后3个月、6个月CIN治疗效果及HPV清除效果进行评价。结果观察组患者阴道出血量及出血时间、阴道排液量及时间、宫颈创面愈合时间均显著小于对照组(t=13.29、6.61、11.46、6.01、4.78,P<0.05),且盆腔疼痛发生率显著低于对照组(χ~2=11.64,P<0.05)。观察组患者术后3个月、术后6个月宫颈细胞学检查CIN治愈率为86.7%、96.7%,分别高于对照组的71.7%、81.7%(χ~2=4.09、6.99,P<0.05)。观察组患者术后3个月、6个月HPV转阴分别为36例、47例,转阴率分别为60.0%、78.3%,对照组术后3个月、6个月HPV转阴分别21例、28例,转阴率分别为35.0%、46.7%。观察组患者术后3个月、6个月的HPV转阴率均显著高于对照组(χ~2=5.64、12.84,P<0.05)。且观察组患者术后3个月、6个月单一基因型及混合基因型HPV转阴率也均显著高于对照组(χ~2≥3.96,P<0.05)。结论保妇康栓联合LEEP术可显著改善CIN伴高危型HPV感染患者术后临床症状,提高CIN治愈率和HPV转阴率。

Abstract： Objective To discuss the clinical efficacy of Baofukang suppository combined with LEEP for treatment of cervical intraepithelial neoplasia （CIN） with high-risk HPV infection. Methods 120 CIN pa- tients with HPV infection admitted in our hospital from January 2015 to January 2016 were selected and ran- domly divided into the observation group and the control group （60 cases in each group） . Both groups were given LEEP therapy, while the observation group was additionally given Baofukang suppository after LEEP. The amount and time of vaginal bleeding, volume and time of vaginal discharge, and time to wound healing were recorded and compared; the efficacy at 3 months and 6 months after surgery as well as the clearance of HPV were evaluated. Results The amount and time of vaginal bleeding, volume and time of vaginal dis- charge and time to cervical wound healing in the observation group were significantly less than those in the control group （t=13.29, 6.61; 11.46, 6.01; 4.78; P〈0.05）, so was the incidence of pelvic pain （X2 = 11.64, P%0.05） . The cure rate of CIN at 3 months and 6 months after operation in the observation group were 86.7% and 96. 7% respectively, significantly higher than those in the control group （71.7% and 81.7%） （X2 =4.09, 6.99, P%0.05） . At 3 months and 6 months after surgery, a6 cases （60.00/6） and 47cases （78.3%） in the observation group turned HPV negative, significantly higher than the 21 cases （35.0%） and 28 cases （46.7%） in control group （Z2=5.64, 12.84, P〈0.05） . And the negative conver- sion rates of single and mixed genotype HPV at 3 months and 6 months after treatment in the observation group were significantly higher than those in the control group （X2=3.96, P〈：0.05） Conclusion Baofu- kang suppository combined with LEEP can significantly improve the clinical symptoms of CIN patients with high-risk HPV infection, improve the cure rate of CIN and reduce the infection rate of HPV.