常见肝脏疾病患者血清视黄醇结合蛋白表达水平及部分肝功能指标联合检测的临床意义

The serum levels and their clinical significance of retinol-binding protein and several liver function index in different types of liver disease

目的探讨肝脏疾病患者血清视黄醇结合蛋白(RBP)、总胆红素(TBIL)、总胆汁酸(TBA)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、前白蛋白(PA)的表达水平及检测的临床意义。方法检测33例肝损害患者、17例肝硬化患者、21例急性肝炎患者、26例慢性肝炎患者和50例对照者的血清RBP、TBIL、TBA、ALT、AST和PA水平。结果各疾病组血清RBP、TBIL、TBA、ALT、AST和PA水平与对照组比较差异有统计学意义(P<0.01);肝损害组RBP、ALT和PA显著高于肝硬化组;肝硬化组ALT低于急性肝炎组,TBIL和TBA显著高于慢性肝炎组;急性肝炎组TBIL和TBA水平高于慢性肝炎组,上述差异均有统计学意义(P<0.05)。RBP和PA在各疾病组均有较高阳性检出率。ALT和AST在肝损害组阳性检出率最高。结论血清RBP、TBIL、TBA、ALT、AST和PA水平的检测能很好的反应肝脏损害情况,为肝病的鉴别诊断、临床治疗监测提供有力依据。

Objective To investigate the serum levels and their clinical application value of refinol - binding protein （ RBP）, total bilirubin（ TBIL）, total bile acid （TBA）, alanine amiotransferase （ALF）, aspartate aminotransferase（AST） and prealbumin （PA） in several types of liver disease. Methods The the serum levels of RBP, TBIL, TBA, ALT, AST and PA were detected in 33 patients with liver damage, 17 patients with cirrhosis, 21 cases of acute hepatitis patients, 26 cases of chronic hepatitis patients and 50 cases of healthy normal controls. Results Compared with the control group, the levels differences of serum RBP, TBIL, TBA, AST, ALT and PA levels in patients groups were statistically significant（P 〈0.01 ） ; the serum levels of RBP, ALT and PA in the liver damage group were significant higher than the cirrhosis group; the ALT level of the cirrhosis group was lower than the acute hepatitis group; TBIL and TBA were higher than the chronic hepatitis group; TBIL and TBA lev- els of the acute hepatitis group were higher than the chronic hepatitis group, with all the differences statistically significant（ P 〈 0.05）. The positive detection rates of RBP and PA in patients groups were significantly higher, and the positive detection rate of ALT and AST was the highest in the liver damage group. Conclusion The detection of serum levels of RBP, TBIL, TBA, ALT, AST and PA could effectively reflect the liver damage, which has great reference value in liver disease diagnose, disease progression and clinical monitoring.