消化道肿瘤患者多项肿瘤标志物联合检查及其临床意义

Joint inspection of multiple tumor markers and its clinical significance in gastric cancer patients

目的探讨消化道肿瘤患者甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、糖类抗原125(CA125)、细胞角蛋白19(CY-211)联合检查及临床意义。方法选择1 356例健康体检者作为健康对照组,1 378例消化道肿瘤患者作为消化道疾病组,其中良性疾病组患者698例,恶性肿瘤患者680例,采用化学发光分析仪检测AFP、CEA、CA19-9、CA125、CY-211;研究各临床指标单独或联合检测诊断的特异性及灵敏度情况。结果与健康对照组、消化道良性疾病组比较,消化道恶性肿瘤组AFP、CEA、CA19-9、CA125、CY-211水平显著上升差异有统计学意义(P<0.05);消化道恶性肿瘤患者诊断中多项肿瘤标志物联合检测特异性、灵敏度明显高于各指标单独检测。结论多项肿瘤标志物联合检测可提高消化道肿瘤患者鉴别诊断的准确性,减少漏诊率,有重要临床价值。

Objective To investigate the joint detection of alpha fetoprotein （AFP）, carcinoembryonic antigen （CEA）, carbo- hydrate antigen 19 - 9 （ CA19 - 9 ）, carbohydrate antigen 125 （ CA 125 ） and Cytokeratin 19 （ CY - 211 ） in patients with gastric cancer and its clinical significance. Methods A total of 1 356 healthy subjects were selected as the control group and 1 378 cases of gastric cancer as the digestive tract disease group, including 698 patients with benign disease and 680 cases of malig- nant tumor. CEA, CAi99, CA125 and CY -211 concentrations were measured by chemiluminescence analyzer. To study the specificity and sensitivity of each clinical index individually or jointly. Results Compared to the control group and the benign disease group, the levels ofAFP, CEA, CA199; CA125, CY -211 of malignant tumor group were significantly higher, with the differences statistically significant（P 〈0.05）. The specificity and sensitivity of joint detection of multiple tumor markers in the diagnosis of digestive tract malignancy were significantly higher than any single detection of each index. Conclusion Joint de- tection of multiple tumor markers can improve the accuracy of differential diagnosis of digestive tract cancer patients and reduce the incidence of missed diagnosis, which has important clinical value.