台州地区3731例高龄孕妇羊水染色体核型分析

Analysis of amniotic fluid karyotyping in 3 731 pregnant women at advanced age in Taizhou area

目的探讨高龄孕妇与胎儿染色体异常发生的关系。方法收集2013年1月-2016年5月浙江省台州医院产前诊断中心的3 731份高龄孕妇羊水染色体结果。将孕妇分为35岁~38岁组和≥39岁组,比较2组的染色体异常发生率。结果共检出染色体异常97例(2.60%),染色体数目异常68例,检出率为1.82%。35岁~38岁组胎儿的21三体综合征和18三体综合征的发生率分别为0.48%和0.16%,≥39岁组的21三体综合征和18三体综合征的发生率分别为1.64%和0.74%,差异均有统计学意义(P<0.05)。结论对于35岁~38岁孕妇建议可先进行血清学筛查再行羊膜腔穿刺,对≥39岁孕妇建议直接行羊膜腔穿刺术。

Objective To discuss the relationship between the fetal chromosomal abnormalities and pregnant women with ad- vanced age. Methods The amniotic fluid karyotyping results of 3 731 women of advanced maternal age in Taizhou Hospital from January 2013 to May 2016 has been collected. The women were divided into two groups： 35 -38 year old group and 〉-39 year old group. The incidence of chromosome abnormality was compared between the two groups Results A total of 97 cases （2.60%） of chromosomal abnormality had been detected. The number of chromosome abnormality was 68 cases, and the detec- tion rate was 1.82%. The incidences of trisomy 21 syndrome and trisomy 18 syndrome in 35 -38 year old group were 0.48% and 0.16%. The incidences of trisomy 21 syndrome and trisomy 18 syndrome in〉39 year old group were 1.64% and 0.74%. The differences were statistically significant（P 〈 0.05）. Conclusion Pregnant women at age of 35 -38 may be recommended for serological screening and amniocentesis, and amniocentesis should be provided directly to women aged 39 years and older.