支气管哮喘患者呼出气一氧化氮浓度与肺功能及血IgE相关性研究

Research of correlation between fractional exhaled nitric oxide concentration and blood IgE in bronchial asthma patients

目的探讨分析支气管哮喘患者呼出气一氧化氮浓度(FeNO)与肺功能及血免疫球蛋白E(IgE)的相关性。方法 42例支气管哮喘患者,根据病情分为哮喘急性发作组(18例)和哮喘缓解组(24例);选取同期健康体检的20例正常者为对照组。比较三组FeNO浓度、肺功能、血IgE水平,分析哮喘急性发作患者FeNO与肺功能、血IgE水平之间的相关性。结果哮喘急性发作组、哮喘缓解组患者FeNO水平均明显高于对照组,且哮喘急性发作组高于哮喘缓解组,差异有统计学意义(P<0.05);哮喘急性发作组、哮喘缓解组患者第一秒用力呼气容积占预计值百分比(FEV1%)均明显低于对照组,且哮喘急性发作组低于哮喘缓解组,差异有统计学意义(P<0.05);哮喘急性发作组、哮喘缓解组患者IgE水平均明显高于对照组,且哮喘急性发作组高于哮喘缓解组,差异有统计学意义(P<0.05)。哮喘急性发作患者FeNO与肺功能FEV1%呈负相关(r=-0.885,P<0.05),与IgE呈正相关(r=0.871,P<0.05)。结论 FeNO与肺功能、血IgE水平具有较为显著的相关性,可以作为哮喘的炎性标志物反映气道炎症水平,对于哮喘的病情诊断、急性发作预测及治疗具有较好的临床参考价值。

Objective To investigate and analyze correlation between fractional exhaled nitric oxide （FeNO） concentration and blood immunoglobulin E （IgE） in bronchial asthma patients. Methods A total of 42 patients with bronchial asthma were divided by disease condition into acute episoded asthma group （18 cases） and remission asthma group （24 cases）. There were another 20 healthy people at the same period as control group. Comparison was made on FeNO concentration, pulmonary function and blood IgE levels in the three groups to analyze correlation between FeNO, pulmonary function and blood IgE level in bronchial asthma patients. Results The acute episoded asthma group and the remission asthma group had obviously higher FeNO level than the control group, and the acute episoded asthma group had higher FeNO level than the remission asthma group. Their difference had statistical significance （P〈O.05）. The acute episoded asthma group and the remission asthma group had much lower percentage of forced expiratory volume in 1 second of predicted value （FEVI%） than the control group, and the acute episoded asthma group had lower FEVI% than the remission asthma group. Their difference had statistical significance （P〈0.05）. The＇ acute episoded asthma group and the remission asthma group had obviously higher IgE level than the control group, and the acute episoded asthma group had higher IgE level than the remission asthma group. Their difference had statistical significance （P〈0.05）. FeNO in acute episoded asthma cases was negatively correlated with FEVI% （r=-0.885, P〈0.05） and positively correlated with IgE （r=0.871, P〈0.05）. Conclusion FeNO shows remarkable correlation between pulmonary function and blood IgE level, and it reflects airway inflammation as the inflammatory mark. It contains excellent value for clinical reference in diagnosis, predication and treatment of asthma and its acute period.