优甲乐联合甲巯咪唑治疗儿童甲亢的疗效与安全性分析

Analysis on curative effect and security of Euthyrox combined with methimazole in the treatment of pediatric hyperthyroidism

目的探究左甲状腺素钠片(优甲乐)联合甲巯咪唑治疗儿童甲状腺功能亢进症(甲亢)的疗效与安全性。方法 98例甲亢患儿,随机分为对照组和观察组,各49例。对照组患儿给予单纯甲巯咪唑治疗,观察组采用优甲乐联合甲巯咪唑治疗,比较两组患儿的临床疗效及不良反应发生情况。结果观察组患儿治疗的总有效率为100.0%,明显高于对照组的89.8%,差异有统计学意义(P<0.05)。对照组患儿发生继发性甲状腺功能减退症3例(6.1%),皮疹2例(4.1%),白细胞减少2例(4.1%),不良反应发生率为14.3%,观察组发生皮疹1例(2.0%),不良反应发生率为2.0%;两组患儿不良反应发生率比较差异有统计学意义(P<0.05)。结论优甲乐联合甲巯咪唑联合治疗儿童甲亢疗效确切,可有效改善患儿的临床症状,安全可靠,值得临床推广应用。

Objective To explore the curative effect and security of levothyroxine sodium tablets（Euthyrox） combined with methimazole in the treatment of pediatric hyperthyroidism. Methods A total of 98 hyperthyroidism children were randomly divided into control group and observation group, with 49 cases in each group. The control group received methimazole for treatment, the observation group received Euthyrox combined with methimazole for treatment. Comparison were made on clinical curative effect and occurrence of adverse reactions in two groups. Results The observation group had obviously higher total effective rate as 100.0% than 89.8% in the control group, and the difference had statistical significance（P〈0.05）. The control group had 3 secondary hypothyroidism cases（6.1%）, 2 skin rash cases（4.1%）, 2 hypoleucocytosis cases（4.1%）, with incidence of adverse reactions as 14.3%, while the observation group had 1 skin rash case（2.0%）, with incidence of adverse reactions as 2.0%. Both groups had statistically significant difference in incidence of adverse reactions（P〈0.05）. Conclusion Combination of Euthyrox and methimazole shows affirmative effect in the treatment of pediatric hyperthyroidism, and it can effectively improve the clinical symptoms of children with safety and reliability. So it is worth clinical promotion and application.