酒精对嗜酒与非嗜酒食蟹猴肝功能的影响

Effectof ethanol intake on liver function in alcoholic and non-alcoholic Macaca Fascicularis

目的:评价酒精对嗜酒与非嗜酒食蟹猴肝功能的影响是否存在差异。方法:按1.5g乙醇/kg灌胃,分别于灌胃0,1.5,4,8和12h采血,血清用全自动生化分析仪分析。结果:嗜酒组和非嗜酒组食蟹猴血清ALT升高明显(P<0.05或P<0.01),但嗜酒组ALT恢复时间比非嗜酒组明显缩短(P<0.01);酒精对嗜酒组食蟹猴TBIL和GGT无明显影响(P>0.05),而非嗜酒组GGT在8h开始出现明显升高(P<0.05);酒精能升高非嗜酒组TG(P<0.01),降低HDL(P<0.05),而对嗜酒组则无影响(P>0.05)。结论:酒精对嗜酒组食蟹猴的肝功能影响弱于非嗜酒组。

Objective：To evaluate the damage of liver function in alcoholic and non-alcoholic Macaca Fascicularis. Methods：Alcohol at the dose of 1.5g/kg was given to monkeys by gavage,then the blood samples were collected at 0,1.5,4,8 and 12h,the serum were detected by automatic biochemistry analyzer.Results：The level of ALT in serum was significantly higher both in alcoholic and non-alcoholic group （P〈0.05 or 0.01）,and the recovery time of ALT in alcoholic group was shorter than non-alcoholic group （P〈0.01）; Ethanol has no effect on TBIL and GGT of alcoholic group,but increased to GGT of non-alcoholic group beginning at 8h （P〈0.05）; Ethanol increased to TG （P〈0.01） and decreased to HDL （P〈0.05） in non-alcoholic group,but not in alcoholic group（P〉0.05）. Conclusions：The liver function effect of ethanol in alcoholic group was weaker than that in non-alcoholic group.