血清镁在多囊卵巢综合征患者中的水平及临床意义

Clinic Effect of Serum Magnesium Levels in Patients with PCOS

目的探究血清镁在多囊卵巢综合征患者中的临床意义。方法选择在我院就诊的40例PCOS患者为观察组。同时,本研究选取40例非PCOS患者为对照组。检测所有患者血清空腹血糖、镁、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇以及胰岛素水平。结果观察组患者TG、胰岛素和HOMA-IR水平均显著高于对照组(P<0.05),而FBS、TC、HDL、LDL水平则没有明显的改变,差异无统计学意义(P>0.05);观察组血清镁水平低于对照组,差异具有统计学意义(P<0.001);血清镁水平诊断PCOS患者的最佳cutoff值为1.505mmol/L,其中灵敏度80.0%,特异性82.5%,AUC值0.829。结论 PCOS患者血清镁水平明显降低,并且患者血清镁诊断PCOS诊断准确性中等,具有一定的临床参考价值。

Objective To evaluate clinic effect of serum magnesium levels in patients with PCOS. Methods A total of 40 PCOS patients as observed group and 40 healthy women as control group were studied in this project. Serum fasting glucose, magnesium, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, and insulin levels were measured in all patients. Results The levels of TG, insulin and HOMA-IR in the observation group were significantly higher than those in the control group （ P 〈 0.05 ）, while the levels of FBS, TC, HDL and LDL were not significantly changed （ P 〉 0.05）. The optimal cutoff value of serum magnesium was 1. 505mmol/L in PCOS patients; the sensitivity was 80.0%, the specificity was 82.5% ; the AUC value was significant （ P 〈 0. 001 ） ; and the serum magnesium level was lower than that of the control group O. 829. Conclusion PCOS patients with serum magnesium levels were significantly reduced, and serum magnesium diagnosis had moderate accuracy for diagnosis of PCOS patients, which indicates a certain clinical reference value.