血浆IL-35水平评价冠心病及其与冠脉Gensini积分和LVEF的相关性

Evaluation of Plasma IL-35 Levels in Patients with Coronary Heart Disease and Their Correlation with Gensini Score and LVEF

目的探讨白细胞介素35(interleukin-35,IL-35)评价冠心病及其与Gensini积分和左心室射血分数(left ventricular ejection fraction,LVEF)的相关性。方法选取2014年1月至2015年12月经冠状动脉造影术(CAG)确诊为冠心病的患者90例,按临床分型,其中稳定型心绞痛(SAP)25例,不稳定型心绞痛(UAP)33例,急性心肌梗死(AMI)32例;选择同期CAG结果提示冠状动脉管腔直径狭窄率<50%的患者50例为对照组。采用酶联免疫法检测血浆IL-35水平,比较冠心病患者与对照组之间的差异。结果与对照组比较,SAP、UAP和AMI组的IL-35水平、冠脉Gensini积分差异均具有统计学意义(P<0.05);与对照组比较,UAP组的左心室射血分数差异无统计学意义(P>0.05),SAP、AMI组的左心室射血分数差异有统计学意义(P<0.05)。IL-35水平与冠脉Gensini积分不相关(r=0.28,P>0.05),但与LVEF呈正相关性(r=0.41,P<0.01)。结论 IL-35水平与冠心病密切相关,可作为CHD评价和预后的指标。

Objective To study the interleukin （IL） -35 in coronary heart disease（CHD） and its correlation with Gensini score and left ventricular ejection fraction （ LVEF）. Methods We selected 90 patients diagnosed as coronary heart disease by coronary angiography （CAG） from January 2014 to 2015. According to clinical classification, identified stable angina （SAP） in 25 cases, unstable angina （UAP） in 33 cases, acute myocardial infarction （AMI） in 32 cases; Select the patients with same period of CAG, and coronary artery lumen diameter stenosis rate of 50% as the control group （n = 50）. The plasma IL-35 level was detected by enzyme-linked immunosorbent assay （ELISA）, and the difference was compared between the patients with coronary heart disease and the control group. Results Compared with the control group, the levels of IL-35 and Gensini in the SAP, UAP and AMI groups were significantly different （ P 〈 0.05 ） ; However, compared with the control group, there was no significant difference in left ventricular ejection fraction （ P 〉 0.05 ） in the UAP group, but the difference of left ventricular ejection fraction between SAP and AMI group was significantly different （P 〈0.05 ）. There was no significant difference in the correlation between IL-35 level and coronary Gensini score （r = 0.28 ,P 〉 0.05 ）, but the level of IL-35 and LVEF was positively correlated （ r =0.41 ,P 〈0.01 ）. Conclusion Plasma levels of IL-10 and IL-35 are closely related with coronary heart disease, which can be used as indicators of CHD evaluation and prognosis.