阿托伐他汀治疗糖尿病伴高血压患者的疗效及对尿β2-MG、SCr、HbAlc水平的影响

Clinical Efficacy of Atorvastatin on Diabetic Patients with Hypertension and its Effects on Urinaryβ2-MG, SCr and HbAlc Levels

【目的】探讨阿托伐他汀治疗糖尿病伴高血压患者的疗效及对患者尿β2微球蛋白（β2-MG）、血肌酐（SCr）、糖化血红蛋白（HbAlc）水平的影响。【方法】将86例糖尿病伴高血压患者随机均分为对照组与观察组，每组43例，对照组给予常规对症治疗，观察组加用阿托伐他汀，比较两组治疗效果，检测并比较两组治疗前后尿β2-MG、SCr、HbAlC、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDLC）及高敏C反应蛋白（hs-CRP）、白介素-6（IL-6）水平，统计治疗不良反应发生率。【结果】观察组总有效率为95．35％（41／43），明显高于对照组79．70％（34／43），其差异有统计学意义（X^2=5．107，P=0．023）；治疗前，两组各指标对比差异无统计学意义（P〉0．05），治疗后，两组β2-MG、SCr、HbAlC、TC、LDL-C、IL6、hs-CRP水平均降低（P〈0．05），观察组B2-MG、SCr、TC、LDL-C、IL-6、hs-CRP下降幅度高于对照组（P〈0．05）。【结论】采用阿托伐他汀干预糖尿病伴高血压患者临床疗效肯定，且可降低患者血脂及炎症因子水平，改善其肾功能。

[Obiective]To investigate the clinical effects of atorvastatin in the treatment of diabetic patients with hy- pertension and its effects on levels of urine β2 microglobulin （β2-MG）, serum creatinine （Scr） and glycosylated hemoglo- bin （HbAlc）. [Methods]Eighty-six patients with diabetes and hypertension were randomly divided into the control group and the observation group, with 43 cases in each group. The control group was given conventional symptomatic treat- ment, while the observation group was additionally treated with atorvastatin. The therapeutic effects were compared be- tween the two groups. The changes of levels of urine β2-MG, Scr, HbAlc, total cholesterol （TC）, triacylglycerol （TG）, high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）, high-sensitivity C reactive protein （hs-CRP）, and interleukin -6 （IL-6） before and after treatment were determined; the incidence of adverse reac- tions was statistically analyzed. [Results] The total effective rate was 95.35 % （41/43） in the observation group, which was higher than that in the control group （79.70%, 34/43） ; the difference was statistically significant （X^2 = 5.107, P = 0.023）. Before treatment, the indexes showed no significant differences between the two groups （ P 〈0.05）. After treat- ment, the levels of 132-MG, Scr, HbAlc, TC, LDL-C, IL-6, and hs-CRP decreased P〈0.05）-the decrease in the obser- vation group was greater than that in the control group （all P 〈0.05）. [Conclusion] Atorvastatin is effective in the treat- ment of diabetic patients with hypertension. It can reduce the levels of blood lipids and inflammatory factors as well as im- prove renal function.