生命早期高脂饮食诱发鼠成年后糖代谢异常的机制研究

Abnormal Glucose Metabolism Induced by High-fat Diet during Early Life of Adult Rats

生命早期包括孕期和哺乳期营养不良对子代一生有长远影响,早期高脂饮食在成年时患肥胖、胰岛素抵抗、糖尿病等代谢性疾病风险明显升高,但其发病机制尚未完全明确。基因改变只能部分解释糖尿病发病率的增加,仅从基因和环境因素很难解释糖尿病急剧上升的发病率。随着对中枢胰岛素抵抗认识的增加,认为中枢对调控外周葡萄糖稳态起着极其重要的作用,越来越多的研究表明这可能是一种表观遗传学机制。综述了生命早期高脂饮食诱发鼠成年后糖代谢异常的机制。

Malnutrition in early life including pregnancy and lactation has long-term effects on children life. A high-fat diet in early life makes a significant increase in adult metabolic diseases such as obesity, insulin resistance, and diabetes, but its pathogenesis is not completely clear. Genetic change can only partly explain the increase of the incidence of diabetes, and the sharp rise in incidence of diabetes is diffi- culi to be explained only from the genetic and environmental factors. With increasing knowledge on the central insulin resistance, the central nervous system plays an important role in the regulation of peripher- al glucose homeostasis, and a growing body of research suggests that this may be a mechanism of epigenetics. This paper reviews the mechanism of sugar metabolism disorders inducedby a high-fat diet during early life in adult rats.