摘要
用乙醇提取方法获取凹叶景天总黄酮,采用灌胃给药的方法,检测凹叶景天总黄酮对小鼠的急性毒性作用;并观察不同剂量凹叶景天总黄酮协同戊巴比妥钠对小鼠的镇静催眠作用;实验结果表明,凹叶景天总黄酮最大耐受量(以生药量计)为60g/kg,且能明显缩短戊巴比妥钠小鼠的潜伏睡眠时间,延长戊巴比妥钠小鼠的睡眠时间,即凹叶景天总黄酮具有镇静催眠作用。
The total flavonoids of Sedum emarginatum is obtained by ethanol extraction, the acute toxicity of total flavonoids of Sedum emarginatum to mice is studied by intragastrie administration, and the sedative and hypnotic effects of total flavonoids of Sedum emarginatum and pentobarbital sodium on mice are observed. Research results shows that the maximum tolerance of total flavonoids of Sedum emarginatum is 60g/kg （raw drug）, it can significantly shorten the latency time of pentobarbital sodium in mice and prolong the sleeping time of pentobarbital mice, that is, the total flavonoids of Sedum emarginatum has sedative hypnotic effect.
作者
常征
王蓉
李洪潮
刘伟
张铁
沈清清
李付惠
胡展育
Chang Zheng Wang Rong Li Hongchao Liu Wei Zhang Tie Shen Qingqing Li Fuhui Hu Zhanyu(School of Environment and Resources, Wenshan University Yunnan Provincial Rresearch and Development Center of Characteristic Plants, Wenshan, Yunnan, 663099)
出处
《保山学院学报》
2017年第2期15-18,共4页
JOURNAL OF BAOSHAN UNIVERSITY
基金
生物科学专业提升专业服务产业能力建设项目(项目编号:ZX20150102)
关键词
凹叶景天
总黄酮
镇静催眠
急性毒性
最大耐受量
Sedum emarginatum
total flavonoids
sedative and hypnotic effects
acute toxicity
maximum tolerance
