某医院临床分离阴沟肠杆菌分布及耐药性变迁

Distribution characteristics and drug resistance change of clinically isolated Enterobacter cloacae in a hospital

目的了解医院临床分离阴沟肠杆菌的分布情况及其耐药性变迁,为合理应用抗菌药物提供科学依据。方法通过细菌分离鉴定技术和回顾性调查方法,对某综合医院住院患者送检临床标本检测结果进行统计分析。结果该医院连续3年从住院患者送检标本中共检出阴沟杆菌298株,主要分离自痰液、伤口分泌物和脓液标本。医院阴沟杆菌分离标本主要来源于综合重症监护病房、神经外科和新生儿科。临床分离的阴沟肠杆菌对临床常用抗菌药物普遍耐药,对碳青霉烯类敏感。临床分离的阴沟杆菌对头孢类抗菌药物的耐药率呈现走高趋势。结论该医院临床分离阴沟肠杆菌主要来自痰液标本,以重症监护病房感染率最高,该细菌对抗菌药物耐药严重,对部分抗菌药物的耐药率呈现发展趋势。

Objective To analyze the distribution characteristics and drug resistance change of clinically isolated E.Cloacae in a certain hospital,in order to provide a scientific basis for antibacterial drugs application.Methods The bacteria isolation and identification method and retrospective investigation were employed to analyze the detection results of clinical samples of patients in a certain general hospital.Results Totally 298 strains of E.Cloacae were detected in three consecutive years,which were mainly isolated from sputum,wound secretion and pus samples.The isolated samples were mainly from ICU,Neurosurgery and NICU.The clinically isolated E.Cloacae were highly resistant to common antibiotics but sensitive to carbapenems.Besides,the resistance rate to cephalosporins showed a rising trend.Conclusion The clinically isolated E.Cloacae in the hospital were mainly from sputum samples.The ICU had the highest infection rate.The E.Cloacae was severely resistant to antibiotics.The resistance rates to some antibacterial drugs displayed a developing trend.