氯吡格雷联合阿司匹林在急性轻度脑梗死治疗中的应用

Application of clopidogrel combined with aspirin in the treatment of acute mild cerebral infarction

目的探究氯吡格雷联合阿司匹林在急性轻度脑梗死治疗中的临床治疗效果。方法 84例急性轻度脑梗死患者,以患者的病情为根据将患者分为对照组(38例)和实验组(46例)。对照组患者采用阿司匹林治疗,实验组患者采用氯吡格雷联合阿司匹林治疗。比较两组患者的临床治疗和不良反应发生情况。结果治疗14 d后,实验组患者治疗有效45例,有效率为97.8%;对照组患者治疗有效31例,有效率为81.6%,实验组患者治疗有效率高于对照组,差异具有统计学意义(P<0.05);治疗后,两组患者美国国立卫生研究院卒中量表(NIHSS)评分低于治疗前,差异具有统计学意义(P<0.05),但两组患者NIHSS评分比较差异无统计学意义(P>0.05)。两组患者不良反应均较轻。结论通过联合氯吡格雷与阿司匹林对急性轻度脑梗死患者实施临床治疗,阻止了卒中的发展,安全系数更高,提升了预后质量。

Objective To investigate clinical effect by clopidogrel combined with aspirin in the treatment of acute mild cerebral infarction. Methods A total of 84 patients with acute mild cerebral infarction were divided by their disease state into control group（38 cases） and experimental group（46 cases）. The control group received aspirin for treatment, and the experimental group received clopidogrel combined with aspirin for treatment. Comparison was made on clinical effect and adverse reactions between the two groups. Results After 14-d treatment, the experimental group had 45 effective cases, with effective rate as 97.8%. The control group had 31 effective cases, with effective rate as 81.6%. The experimental group had higher effective rate in treatment than the control group, and the difference had statistical significance（P〈0.05）. After treatment, both groups had lower National Institutes of Health Stroke Scale（NIHSS） scores than those before treatment, and the difference had statistical significance（P〈0.05）, while there was no statistically significant difference of NIHSS scores between the two groups（P〉0.05）. Both groups had mild adverse reactions. Conclusion Combination of clopidogrel and aspirin in clinical treatment of acute mild cerebral infarction inhibit development of stroke with high safety factor, and it improves quality of prognosis.