3种他汀类药物治疗高胆固醇血症的疗效与经济学探讨

Efficacy and Economic Study of Three Kinds of Statins in Treatment of Hypercholesterolemia

目的:探讨3种他汀类药物治疗高胆固醇血症的疗效与经济学价值。方法:选取2015年6月—2016年9月于解放军第153中心医院接受治疗的180例高胆固醇血症患者作为研究对象,按随机数字表法分为A、B、C三组。A组患者给予辛伐他汀片,1次20 mg,1日1次;B组患者给予阿托伐他汀钙片,1次20 mg,1日1次;C组患者给予瑞舒伐他汀钙片,1次10 mg,1日1次,治疗2个月后,比较三组患者的疗效与不良反应,并运用药物经济学方法进行成本-效果分析。结果:三组患者的血脂水平均较治疗前明显改善,但三组间的差异无统计学意义(P>0.05);A、B、C组患者的总有效率分别为91.7%(55/60)、93.3%(56/60)、90.0%(54/60),不良反应发生率分别为8.3%(5/60)、11.7%(7/60)、8.3%(5/60),差异均无统计学意义(P>0.05)。A、B、C组患者的治疗成本分别为204.0、534.0、294.0元;A组方案的经济学价值较高。结论:辛伐他汀片治疗高胆固醇血症安全、有效、经济,为最佳治疗方案。

OBJECTIVE：To probe into the efficacy and economic study of three kinds of statins in treatment of hypercholesterolemia. METHODS： 180 patients with hypercholesterolemia admitted into the 153th Central Hospital of PLA from Jun. 2015 to Sept. 2016 were selected to be divided into group A, group B and group C via the random number table. Group A were treated with simvastatin tablets 20 mg once daily, group B received atorvastatin calcium tablets 20 mg once daily, and group C were given rosuvastatin calcium tablets 10 mg once daily. The efficacy and adverse drug reactions of three groups were compared after treatment of 2 onyhs. And cost-effectiveness was analyzed by pharmacoeconomics method. RESULTS： The blood lipid of three groups had been improved significantly, yet there was no statistical significance（P 〉0. 05）. The total effective rate of three groups were respectively 91.7% （55/60）, 93.3% （56/60） and 90. 0% （54/60）, the incidence of adverse drug reactions were respectively 8.3% （5/60）, 11.7% （7/60） and 8.3% （5/60）, with no statistically significant difference（P 〉 0. 05）. The treatment costs were respectively 204. 0 yuan, 534. 0 yuan and 294. 0 yuan, and the economic value of group A was relatively high. CONCLUSIONS ： Simvastatin tablets is safe, effective and economical in the treatment of hypercholesterolemia. It is the optimized treatment regimen.