临床药师对化疗所致恶心呕吐现状的调查及药学监护

Investigation and Pharmaceutical Care on Chemotherapy Induced Nausea and Vomiting by Clinical Pharmacists

目的:探讨临床药师对肿瘤患者化疗所致恶心呕吐控制情况的药物监护。方法:采用问卷调查的方式,调查化疗所致恶心呕吐的控制情况、止吐用药方案和其对患者生活的影响。调查结果采用描述性分析,并对患者止吐药物的使用情况进行评价。结果:共纳入96例符合标准的患者。多日高度致吐风险组34例患者中,延迟期恶心呕吐的缓解率略低于急性期恶心呕吐的缓解率。单日化疗对患者的生活功能影响较小,多日化疗对患者的生活功能有一定影响。高度致吐风险组符合指南标准方案者20例(占58.82%),中度致吐风险组46例(占79.31%),低度致吐风险组4例(占100.00%)。结论:化疗所致恶心呕吐尚未无有效治疗方案,临床药师加强药学监护,方可提高治疗效果,促进合理用药。

OBJECTIVE： To investigate the pharmaceutical care on chemotherapy induced nausea and vomiting（ CINV） by clinical pharmacists. METHODS： Questionnaire survey was adopted to investigate the CINV control,antiemetic medication regimens and effects of CINV on the life during chemotherapy. The investigation results was analyzed by descriptive analysis,and evaluation was conducted on the application of antiemetic drugs. RESULTS：Totally 96 patients were involved in the research. In the highly emetogenic chemotherapy group（ 34 cases）,the remission rate of nausea and vomiting in period of delay was significantly higher than that in acute stage. Single chemotherapy had few effects on the vital function of patients,yet continuous chemotherapy did. 20 cases（ 58. 82%）of highly emetogenic chemotherapy group match the guideline,46 cases（ 79. 31%） of moderately group,and 4 cases（ 100. 00%） of lowly group. CONCLUSIONS： Among the patients with chemotherapy,CINV control has not achieved satisfactory results,clinical pharmacists need to reinforce effective pharmaceutical care,so as to promote rational use of drugs,and improve the therapeutic effects.