吡拉西坦注射液联合甘露醇注射液治疗脑出血后脑水肿的疗效观察

Observation on Efficacy of Piracetam Injections Combined with Mannitol Injections in Treatment of Brain Edema After Intracerebral Hemorrhage

目的:探讨吡拉西坦注射液联合甘露醇注射液治疗脑出血后脑水肿的疗效。方法:选取2015年10月—2016年12月新余市新钢中心医院收治的脑出血后脑水肿患者122例作为研究对象,按照入院顺序分组,单号为观察组,双号为对照组,每组61例。对照组患者给予甘露醇注射液进行常规治疗,观察组患者在对照组的基础上加用吡拉西坦注射液治疗。比较两组患者血肿大小、水肿体积的差异,采用健康调查量表(the MOS item short from health survey,SF-36)评分对患者的生活质量进行评定,结果:治疗后,观察组患者的血肿大小、水肿体积分别为(10.83±2.09)、(9.62±2.01)ml,明显小于对照组的(14.67±2.16)、(13.83±3.14)ml,差异均有统计学意义(P<0.05);观察组患者各项SF-36评分均明显高于对照组,差异均有统计学意义(P<0.05)。结论:吡拉西坦注射液联合甘露醇注射液治疗脑出血后脑水肿的疗效确切,可有效促进患者脑水肿的吸收,降低颅内压,改善神经功能,提高生活质量。

OBJECTIVE： To probe into the efficacy of piracetam injections combined with mannitol Injections in treatment of brain edema after intracerebral hemorrhage. METHODS： 122 patients with brain edema after intracerebral hemorrhage admitted into Xinyu New Steel Central Hospital from Oct. 2015 to Dec. 2016 were according to admission order grouping, single number as the observation group, double number as the control group, with 61 cases in each. The control group were given marmitol Injections the conventional treatment, while the observation group additionally received piracetam injections based on the control group. Difference of hematoma size, edema volume of two groups were compared, and the SF-36 scale was used to evaluate the quality of life of patients. RESULTS：Mter treatment, the hematoma size, edema volume of observation group were respectively （10. 83 ± 2. 09） ml and （9. 62 ± 2. 01 ） ml, significantly lower than those of control group （14. 67 ±2. 16） ml and（13. 83 ±3. 14） ml, with statistically significant difference（P 〈0. 05）. The SF-36 score of observation group was significantly higher than that of control group, with statistically significant difference （P 〈 0. 05）. CONCLUSIONS：The efficacy of piracetam injections combined with mannitol Injections in treatment of brain edema after intracerebral hemorrhage is accurate, which can effectively promote the absorption of cerebral edema, reduce intracranial pressure, improve neurological function and improve the quality of life of patients.