CYP450基因多态性对非创伤性股骨头坏死的影响

Influence of CYP450 gene polymorphism on non-traumatic osteonecrosis of femoral head:a review

酒精和激素是引起非创伤性股骨头坏死的常见原因,随着非创伤性股骨头坏死发病机制研究的逐渐深入,部分研究认为酒精和激素可影响肝酶的代谢,从而对非创伤性股骨头坏死的发生、发展产生重要影响。细胞色素450酶(cytochrome P450,CYP450)作为肝酶常见的一种类型,其作用机制的研究逐渐得到医学研究者的青睐。随着CYP450研究深入,部分研究认为CYP450易感基因位点的变化可能是非创伤性股骨头坏死的发病机制,本文通过综述CYP450相关基因的多态性研究进展,对临床以及实验研究非创伤性股骨头坏死作用机制提供一定的参考和借鉴。

Alcohol and hormones are two common reasons for non-traumatic osteonecrosis of the femoral head, and in- depth research in the pathogenesis of the disease has shown that alcohol and hormones may influence on the metabolism of liver enzyme, and thus exert significant impacts on the pathogenesis and progression of non-traumatic osteonecrosis of the femoral head. The mechanism of action of cytochrome P450 （CYP450）, a common liver enzyme, is drawing more and more attention of the medical researchers. According to some of the investigations, the changes in the susceptibility gene loci of CYP450 may play roles in pathogenesis of non-traumatic osteonecrosis of the femoral head. This thesis reviews current research on CYP450 gene polymorphism and provides references for clinical and experimental studies of the disease.