摘要
人体肠道中的微生物与宿主相互作用。近年来,人们逐渐认识到肠道菌群与心血管疾病之间的关联性,甚至其中的因果关系及产生的分子机制,其中包括肠道微生物生成的氧化三甲胺(TMAO)在动脉粥样硬化性心脏病和心力衰竭的发病机制中的作用和短链脂肪酸及其受体在血压调节中的作用等代谢途径。
The intestine microbiota and the host interacts with each other.Resently,the association and causality between gut microbiota and cardiovascular diseases have been well studied.Some underlying mechanisms,especially metabolic pathways are known,including the role of trimethylamine N-oxide in the pathogenesis of atherosclerotic heart disease and heart failure and that of short chain fatty acids and their receptors in blood pressure regulation.
作者
王燕
蔡军
WANG Yan CAI Jun(Hypertension Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases Fuwai Hospital, CAMS ＆ PUMC, Beijing, 100037,China)
出处
《基础医学与临床》
CSCD
2017年第5期729-733,共5页
Basic and Clinical Medicine
