以MACC1为中心的肿瘤转移调控网络研究进展

MACC1 regulatory network in tumor metastasis

结肠癌转移相关基因1(metastasis-associated in colon cancer-1,MACC1)最早在结直肠癌中被鉴定.此后发现其在多种肿瘤中表达异常升高,且与肿瘤转移呈正相关,与患者预后呈负相关,具有明确的促肿瘤转移作用,是一个潜在的抗肿瘤治疗靶点.近年来对M A C C1调控机制的研究日益深入,其被发现在维持肿瘤相关信号的活性,转录激活部分促癌基因,调控上皮-间质转化,促进肿瘤血管形成等方面具有重要作用.而其自身的表达又受到非编码RNA、单核苷酸多态性的调控或影响.一个以MACC1为中心的肿瘤生长转移调控网络正逐渐浮出水面.本综述拟对上述研究进展做一综述.

The MACC1 gene was firstly identified in colorectal cancer. Recently, abnormal upregulation of MACC1 has been detected in multiple tumors. The expression of MACC1 is shown to be positively associated with tumor metastasis, but negatively with prognosis of patients, and it represents a potential therapeutic target for anti-tumor strategies. MACC1 has increasingly emerged as a key regulator in metastatic processes, and it has been identified to be able to maintain multiple tumor-associated signaling pathways, transactivate oncogenic genes, and regulate epithelial-mesenchymal transition and tumor vascularization. On the other hand, MACC1 is regulated and influenced by non-coding RNAs and SNPs. The present review will summarize the recent progress in understanding the role of the MACC1 regulatory network in tumor metastasis.