阳江地区女性解脲脲原体感染及耐药性分析

Analysis of Infection and Drug-Resistant of Ureaplasma Urealyticum of the Women in Yangjiang

目的研究阳江地区女性泌尿生殖道解脲脲原体感染和药敏变化情况,为指导临床合理用药提供理论依据。方法支原体药敏试剂盒检测7595例宫颈分泌物,分析其感染情况和常用抗生素的药敏状况。结果7595例受检患者解脲脲原体培养阳性3460例;各年龄组女性解脲脲原体感染阳性率差异有统计学意义(X^2=12.0199,P<0.05),不同年份的阳性率无明显差异(X^2=3.9876,P>0.05)。结果显示女性感染者对氧氟沙星、罗红霉素耐药率较高,不同年龄段女性对强力霉素、美满霉素、克拉霉素和罗红霉素的耐药率有所不同。各抗生素耐药率均随时间推移呈先升高后降低的趋势。结论女性患者中解脲脲原体对四环素类的美满霉素和大环内酯类的交沙霉素的敏感性较高,可作为治疗解脲脲原体感染的首选抗生素和经验用药。

Objective To study the infection and drug susceptibility of Ureaplasma urealyticum in female genitouri- nary tract in Yangjiang area, and to provide theoretical basis for guiding clinical rational drug use. Methods 7595 cases of cervical secretions were detected by the mycoplasma drug sensitivity kit produced by Zhuhai Livzon Biotechnology Research Institute, and the infection status and susceptibility of common antibiotics were analyzed. Results In7595 cases of patients with ureaplasma urealyticum, there were positive culture of 3460 cases. T The positive rate of Ureaplasma urealyticum infec- tion in all age groups was statistically significant （ 12. 0199, P 〈 0.05 ）. There was no significant difference in the positive rate of different years （3. 9876, P 〉 0.05 ）. The results showed that women infected with ofloxacin, roxithromycin resistance rate is higher, different age women on doxycycline, minocycline, elarithromycin and roxithromyein resistance rate is different. The antibiotic resistance rate of each antibiotic increased first and then decreased with the passage of time. Conclusion The sensitivity in women of Ureaplasma urealyticum is being high in minocyeline and josamycin. Test of drug - resistence of ureaplasma urealyticum can guide reasonable clinical medication.