布地奈德联合特布他林雾化吸入治疗哮喘急性发作的疗效观察

Observation of curative effect of budesonide combined with terbutaline aerosol inhalation in the treatment of acute asthma

目的 探讨布地奈德联合特布他林雾化吸入治疗哮喘急性发作的疗效,为临床治疗方案的制定提供参考.方法 选取哮喘急性发作的患者118例,随机数字表法分为观察组和对照组各59例.对照组采用布地奈德雾化吸入,观察组采用布地奈德联合特布他林雾化吸入.对比两组患者的临床疗效及其临床症状、体征的消失时间;对比两组患者的肺功能检查结果以及不良反应的发生情况.结果 观察组总有效率为72.88%,显著高于对照组的52.54%（χ^2=5.218,P〈0.05）;观察组气促消失时间为（4.01±1.42）d,咳嗽消失时间为（6.58±1.51）d,肺部啰音消失时间为（7.02±2.27）d,均显著短于对照组的（5.71±1.59）d、（8.52±1.97）d、（8.69±2.61）d（t=4.557、4.421、4.659,均P〈0.05）;观察组治疗后的FEV1为（2.35±0.67）L,FVC为（2.76±0.62）L,PEF为（2.91±0.49）L,均显著高于对照组治疗后的（2.09±0.57）L、（2.31±0.51）L、（2.48±0.59）L（t=3.625、3.641、3.887,均P〈0.05）;两组患者均未发生严重不良反应.结论 布地奈德联合特布他林雾化吸入可迅速缓解哮喘急性发作患者的临床症状,改善患者的肺功能,提高临床治疗效果,且具有良好的安全性.

Objective To investigate the efficacy of budesonide combined with terbutaline atomization inhalation in the treatment of acute asthma attacks, and to provide reference for clinical treatment.Methods 118 patients with acute asthma attack were selected and randomly divided into observation group and control group, 59 cases in each group.The control group was treated with budesonide inhalation, the observation group was treated with budesonide combined with terbutaline aerosol inhalation The clinical efficacy of the two groups, clinical symptoms and signs of the disappearance time were compared, the pulmonary function test results and the occurrence of adverse reactions were compared.Results In the observation group,the total effective rate was 72.88%, which was significantly higher than 52.54% of the control group （χ^2=5.218,P〈0.05）.The disappear time of shortness breath, cough, pulmonary rales in the observation group were （4.01±1.42）d, （6.58±1.51）d, （7.02±227）d, which were significantly shorter than （5.71±1.59）d,（8.52±1.97）d,（8.69±2.61）d in the control group （t=4.557,4.421,4.659,all P〈0.05）.After treatment, the FEV1,FVC and peak expiratory flow （PEF） of the observation group were （2.35±0.67）L, （2.76±0.62）L, （2.91±0.49）L, which were significantly higher than（2.09±0.57）L,（2.31±0.51）L,（2.48±0.59）L of the control group （t=3.625,3.641,3.887,all P〈0.05）.The two groups had no serious adverse reactions.Conclusion Budesonide combined with terbutaline atomization inhalation can relieve the clinical symptoms of patients with acute asthma,improve lung function,improve the clinical treatment effect and has good security.