甲状腺片联合左甲状腺素治疗甲状腺功能减退的临床疗效分析

Analysis of the clinical effect of thyroid tablets combined with superior thyroid in the treatment of patients with hypothyroidism

目的 探讨甲状腺片与左甲状腺素联合治疗甲状腺功能减退的临床疗效.方法 选取90例甲状腺功能减退的患者,采用随机数字表法将其分为对照组和观察组,对照组给予甲状腺片进行治疗,观察组给予甲状腺片联合使用左甲状腺素片进行治疗.观察两组治疗1年后的临床疗效、主要指标变化及不良反应等.结果 经治疗后,观察组临床总有效率95.6%,与对照组的82.2%差异有统计学意义（χ^2=1.995,P〈0.05）;血清中T3、T4、TSH水平较治疗前均发生了显著性改变,差异均有统计学意义（t对照组=3.021、3.146、2.891,均P〈0.01,t观察组=2.984、2.915、3.422,均P〈0.01）,治疗组血清中T3、T4、TSH水平改善程度明显优于对照组,差异均有统计学意义（t=3.683、4.266、2.999,均P〈0.05）;两组不良反应比较,差异无统计学意义（χ^2=0.192,P〉0.05）.结论 采用甲状腺片联合左甲状腺素治疗甲状腺功能减退,可显著改善患者的临床症状,提高临床疗效,且安全性较好,具有临床借鉴意义.

Objective Investigate the clinical effect of thyroid tablets combined with superior thyroid therapy in the treatment of hypothyroidism.Methods 90 patients with hypothyroidism were selected and divided into control group and observation group by random digit table,the control group was given Thyroid Tablets treatment,the observation group was treated with thyroid tablets combined with the use of left thyroid hormone tablets.To investigate the clinical efficacy of 1 groups of patients after two years of treatment,the main indicators of changes and adverse reactions,etc.Results After treatment,the total efficiency of the observation group 95.6% compared with the control group 82.2%,the difference was statistically significant （χ^2=1.995,P〈0.05）;the serum T3,T4 and TSH levels before treatment had changed significantly,there were statistically significant differences in the control group （tcontrol group=3.021,3.146,2.891,all P〈0.01,tobservation group=2.984,2.915,3.422,all P〈0.01）,improved significantly better than the control group,T3,T4,TSH level in serum,the difference was statistically significant （t=3.683,4.266,2.999,all P〈0.05）;The adverse reactions of the two groups.There was no statistically significant difference （χ^2=0.192,P〉0.05）.Conclusion The combination of thyroid tablets and superior thyroid in the treatment of hypothyroidism can significantly improve the clinical symptoms of patients,improve clinical efficacy,and the safety is better,has a larger clinical significance.