摘要
目的:探究血小板淋巴细胞比值(PLR)和中性粒细胞淋巴细胞比值(NLR)在病毒性肝脏疾病进展及预后中临床意义。方法:回顾分析我院电子病历系统数据,依据纳入排除标准,纳入2013年1月至2015年6月来我院就诊的HBV和HCV感染相关肝脏疾病和非病毒性肝脏疾病患者共计309例和健康对照40例(HC组),肝脏疾病患者分为慢性乙型肝炎未治疗(HBV-UT)组、清除(HBV-Cl)组、未清除(HBV-UC)组、肝硬化(HBV-Cirr)组、肝癌(HBV-HCC)组,慢性丙型肝炎未治疗(HCV-UT)组、清除(HCV-Cl)组、未清除(HCV-UC)组、肝硬化(HCV-Cirr)组、肝癌(UV-HCC)组,非病毒性肝炎/肝损伤(UV-Ht)组、肝硬化(UVCirr)组、肝癌(UV-HCC)组,比较各组PLR和NLR差异。结果:HCV-Cl组PLR明显高于HCV-UT、HCV-UC组(P<0.05),HCV-UT、HCV-UC组NLR明显低于HC组(P<0.05)。HCV-UT、HCV-Cirr、HCV-HCC组较之HC组,PLR均显著降低,差异有统计学意义(P<0.05),并且HCV-Cirr、HCV-HCC组较之HCV-UT组PLR也降低,差异有统计学意义(P<0.05),但HCV-Cirr组与HCV-HCC组PLR无差异。结论:PLR和NLR在病毒性肝脏疾病的进展、预后中有着一定的指示作用,尤其HCV感染中,PLR与其病毒学应答和疾病进展密切相关。
Objective: To explore the clinical significance of PLR and NLR in the progression and prognosis ofviral liver disease. Methods: By retrospective analysis of the electronic medical records system data,according to the inclusion and exclusion criteria,a total of 309 patients with liver disease associated with HBV infection,HCV infection or non-viral liver disease were included from January 2013 to June 2015. The group of healthy controls( HC) consisted of 40 healthy individuals. The patients were divided into HBV untreated( HBV-UT) group,HBV cleared( HBV-Cl) group,HBV uncleared( HBV-UC) group,HBV-cirrhosis( HBV-Cirr) group,HBV-hepatocellular cancer( HBV-HCC) group; HCV untreated( HCV-UT) group,HCV cleared( HCV-Cl) group,HCV uncleared( HCV-UC) group,HCV-cirrhosis( HCV-Cirr) group,HCV-hepatocellular cancer( UV-HCC) group; Virus-unrelated hepatitis / liver damage( UV-Ht) group,virus-unrelated cirrhosis( UV-Cirr) group,virus-unrelated hepatocellular cancer( UV-HCC) group. The differences of PLR and NLR in each groups were compared. Results: PLR of HCVCl group was obviously higher than that of HCV-UT and HCV-UC group( P 〈 0. 05),NLR of HCV-UT and HCVUC group were lower than that of HC group( P 〈 0. 05). Compared with HC group,PLR of HCV-UT,HCV-Cirr and HCV-HCC group were significantly lower,and the differences were statistically significant( P 〈 0. 05). Compared with HCV-UT,PLR of HCV-Cirr and HCV-HCC group reduce and the differences were statistically significant( P 〈0. 05),while PLR of HCV-Cirr and HCV-HCC group showed no difference. Conclusion: PLR and NLR have a certain indicative function in the progression and prognosis of viral liver disease,especially in patients with HCVassociated liver disease.
出处
《东南大学学报(医学版)》
CAS
北大核心
2016年第6期854-860,共7页
Journal of Southeast University(Medical Science Edition)
基金
国家自然科学基金资助项目(No.U1204811)
中国博士后科学基金第七批特别资助项目(2014T70688)
河南省教育厅科学技术研究重点项目(13A310622)
河南省医学科技攻关计划普通项目(201303075
201403035)
郑州大学第一附属医院青年创新项目(201301)
关键词
血小板淋巴细胞比值
中性粒细胞淋巴细胞比值
肝炎
肝硬化
肝癌
platelet-to-lymphocyte ratio
neutrophil-to-lymphocyte ratio
hepatitis
cirrhosis
hepatocellular cancer