乳腺癌体积倍增时间与ER、PR、HER-2及Ki-67的相关性研究

Correlation of ER,PR,HER-2,Ki-67 and tumor volume doubling time in breast cancer

目的：使用三维超声评估乳腺癌的肿瘤体积倍增时间（tumour volume doubling time,TVDT）,分析TVDT与病理学指标的相关性。方法：69例至少有2次三维超声检查（间隔至少3个月）的乳腺癌病人纳入研究。根据公式计算出TVDT,并与病理学指标进行统计学分析。结果：本组TVDT平均天数为（185±126）d（66~521 d,中位天数164 d）。乳腺癌患者不同年龄、月经状态、病理类型、淋巴结转移情况、组织学分级、诺丁汉预后指数（Nottingham prognostic index,NPI）及HER-2的患者TVDT差异无统计学意义（P〉0.05）。不同乳腺癌家族史、ER、PR、Ki-67及乳腺癌分子亚型的乳腺癌患者TVDT差异有统计学意义（P〈0.05）。乳腺癌分子亚型中ER阳性组TVDT为（234±156）d,HER-2过表达组为（184±71）d,三阴性组为（127±48）d。结论：乳腺癌TVDT与乳腺癌预后分子病理学标志物ER、PR、Ki-67及分子亚型有关,其中三阴性乳腺癌生长最快。

Objective： To evaluate tumor volume doubling time（ TVDT） of breast cancer with three-dimensional ultrasound（ 3D-US）,and analyze the correlation between TVDT and pathological indexes. Methods： A total of 69 patients with breast cancer were enrolled in the study. Patients with breast cancer scanned by 3D-US at least twice（ with an interval of 3 months or more） were recruited. The results of TVDT were calculated according to the formula and statistically compared with pathological indexes. Results： Mean TVDT was（ 185 ± 126） d（ range 66 to 521,median 164）. The mean TVDT of patients with ER positive was（ 234 ± 156） d,with overexpression of HER-2 was（ 184 ± 71） d,and with triple-negative breast cancer was（ 127 ± 48） d. There were no statistic significance in TVDT between different patient age,menstrual cyclicity,pathological classification, lymph node metastasis,histological grade,Nottingham prognostic index（ NPI） and HER-2 expression（ all P 〉 0. 05）. There were significant relationships between TVDT and a family history,ER,PR,Ki-67 or molecular subtypes of breast cancer（ all P 〈0. 05）. Conclusion： TVDT of breast cancer is associated with prognostic biomarkers of ER,PR,Ki-67 and molecular subtypes. Triple-negative breast cancer has the fastest growth rate.