红霉素、阿奇霉素在小儿支原体肺炎治疗中的应用观察

Application of erythromycin and azithromycin in the treatment of mycoplasma pneumonia in children

目的:探讨小儿支原体肺炎采用红霉素、阿奇霉素序贯治疗的临床效果。方法:选取100例支原体肺炎患儿为研究对象,采用数字表抽取法随机分组,就阿奇霉素序贯治疗(对照组,n=50)与红霉素、阿奇霉素序贯治疗(观察组,n=50)效果展开对比。结果:观察组支原体肺炎患儿总有效率为98%,明显高于对照组患儿(82%),差异有统计学意义(P<0.05)。观察组患儿退热、止咳、住院时间均明显短于对照组,差异有统计学意义(P<0.05)。观察组出现胃肠道症状如恶心、呕吐等9例,占18%,患儿可耐受,未影响治疗。对照组出现胃肠道症状8例,占16%,组间比较差异无统计学意义(P>0.05)。结论:采用红霉素与阿奇霉素联合序贯疗法对支原体肺炎患儿治疗,可明显缩短症状消失时间、住院时间,较大程度上提高了治疗效果,且未增加不良反应,对保障患儿预后价值显著。

Objective To explore the clinical effect of sequential therapy of erythromycin and azithromycin in the treatment of mycoplasma pneumonia in children. Method 100 cases of children with mycoplasma pneumonia treated in our hospital were se-lected. Using digital table extraction method,they were divided into control group 50 cases and observation group 50 cases. The control group was treated with Azithromycin Sequential therapy,and the observation group was treated with erythromycin and Az-ithromycin Sequential therapy,and the effect of the two groups were compared. Results The total effective rate of the observation group was 98% ,which was significantly higher than that of the control group （82% ） ,and there was statistical difference （P 〈 0.05）. The observation group with fever,cough and hospitalization time were significantly shorter than the control group （P 〈 0. 05）. In the observation group, gastrointestinal symptoms such as nausea, vomiting and other 9 cases, accounting for 18% , the patient can be tolerated, did not affect the treatment. In the control group, there were 8 cases of gastrointestinal symptoms, ac-counting for 16% ,and there was no difference between groups （P 〉0. 05）. Conclusion The treatment of erythromycin and Az-ithromycin Sequential Therapy in children with mycoplasma pneumonia,can significantly reduce the symptoms disappeared time, hospitalization time, greatly improve the therapeutic effect and adverse reaction. It has significant prognostic value in the protection of children.