米力农对老年心力衰竭心功能及血清hs-CRP、TNF-α、IL-6水平的影响

Effect of milrinone on cardiac function in elderly patients with heart failure and its impact on serum hs-CRP,TNF-α and IL-6

目的:探讨米力农对老年心力衰竭患者心功能及血清hs-CRP、TNF-α、IL-6水平的影响。方法:将72例老年慢性心力衰竭患者随机分为观察组(n=36)与对照组(n=36),对照组给予常规抗心衰治疗,观察组患者联合应用米力农治疗,比较两组患者临床疗效及治疗前后心功能指标(超声心动图、血清NT-pro BNP)及血清hs-CRP、TNF-α、IL-6水平的变化。结果:治疗后,观察组治疗总有效率为91.67%,较对照组(75.00%)明显升高,差异有有统计学意义(P<0.05);与治疗前比较,LVEF在两组患者均获得了明显升高LVEDd及血清NT-pro BNP水平明显下降,观察组患者上述指标均优于对照组患者(P<0.05);治疗后,血清hs-CRP、TNF-α及IL-6水平在两组患者均降低明显,且观察组上述指标明显低于对照组,差异均有统计学意义(P<0.05)。结论:短期使用米力农治疗老年慢性心力衰竭患者,可以明显改善患者的心功能、抑制炎症反应、提高临床疗效。

Objective：To investigate the effect of milrinone on cardiac function in elderly patients with heart failure and its impact on serum hs-CRP,TNF-αand IL-6.Methods：72cases of elderly patients with chronic heart failure were randomly divided into observation group（n=36）and control group（n=36）,the control group received routine anti heart failure treatment,observation of combined application of milrinone in the treatment group,compared two groups of patients with clinical curative effect,cardiac function index before and after treatment between the two groups（echocardiography,serum NT-pro BNP）index,serum NT-pro changes and serum hs-CRP,TNFalpha,IL-6level.Results：after treatment,the total efficiency of treatment in the observation group was 91.67%,compared with the control group（75%）was significantly increased,there was significant difference（P 0.05）;compared with before treatment,LVEF in the two groups of patients were significantly increased LVEDd and serum NT-pro BNP levels were significantly decreased,the observation group of patients with these indexes better than the control group（P〈0.05）;after treatment,serum hs-CRP,TNF-alpha and IL-6levels in the two groups of patients were significantly decreased,and the observation group were lower than the control group,there were significant differences（P〈0.05）.Conclusion：For the short-term use of milrinone in the treatment of elderly patients with chronic heart failure can significantly improve cardiac function and inhibit inflammatory reaction and improve the clinical efficacy.