辛伐他汀联合阿司匹林治疗脑血栓190例疗效观察

The clinical curative effect observation on simvastatin combined with Aspirinin in the treatment of patients with cerebral thrombosis

目的:探讨辛伐他汀联合阿司匹林治疗脑血栓患者的临床效果。方法:将380例脑血栓患者按随机分为两组,对照组在常规治疗基础上给予阿司匹林肠溶片口服,观察组在对照组基础上再给予辛伐他汀口服,比较两组患者颈动脉内膜中层厚度(IMT)和颈动脉斑块面积变化TG、TC、HDL-C、LDL-C、Barthel指数、NIHSS量表评分等指标变化。结果:治疗后两组患者IMT、斑块面积、TG、TC及LDL-C均显著降低(P<0.05),且观察组治疗后症状改善均明显好于对照组(P<0.05),两组HDL-C治疗前后未发生明显改变(P>0.05);治疗后两组患者NIHSS显著降低及Barthel指数评分显著升高(P<0.05),且观察组改变更明显,均明显好于对照组(P<0.05)。结论:采用辛伐他汀联合阿司匹林治疗脑血栓疗效显著,减轻神经功能缺损,缩小颈动脉斑块面积及厚度。

Objective：To explore the clinical effect of the combination of simvastatin and Aspirin in the treat-ment of patients with cerebral thrombosis. Methods： 380 cases with cerebral thrombosis,according to random number table method. The control group were given Aspirin enteric-coated tablets, while the observation group of patients were given simvastatin based on the control group. Compared the change of IMT and carotid plaque area,TG,TC, HDL-C, LDL-C,Barthel index,NIHSS scale score. Results： After treatment, IMT,plaque area,TG, TC、 LDL-C、 NIH- SS of two groups of patients were significantly lower（P〈0. 05） ,and the improvement of symptoms after treatment in observation group were better than that in the control group（P〈0. 05）. HDL-C of two groups did not significantly change after the treatment（P〉0. 05）. Conclusion：Simvastatin combined with Aspirin to treat patients with cerebral thrombus can reduce the nerve function defect, narrow carotid artery plaque area. Therefore, it is worth popularizing in clinical application.