富含亮氨酸蛋白LRP130抗体在恶性肿瘤中的表达和临床意义

Expressions and clinical significance of LRPPRC in cancer

目的:探讨富含亮氨酸蛋白LRP130抗体(LRPPRC)在胃癌、宫颈癌和前列腺癌的表达和临床意义。方法:应用免疫组化法检测120例胃癌、80例宫颈癌和198例前列腺癌组织中LRPPRC的表达;分析LRPPRC的表达和临床病理学参数的关系。结果:胃癌和正常胃组织LRPPRC的高表达率分别为71.7%(86/120)和21.7%(13/60),二者差异有统计学意义(P<0.001);宫颈癌和正常宫颈组织LRPPRC的高表达率分别为76.3%(61/80)和27.5%(11/40),二者差异有统计学意义(P<0.001);前列腺癌和前列腺增生组织LRPPRC的高表达率分别为61.6%(122/198)和18.0%(18/100),二者差异有统计学意义(P<0.001)。LRPPRC的高表达与前列腺癌患者的Gleason评分、血清PSA水平、雄激素阻断治疗后PSA下降水平和转移部位的数量相比呈显著正相关(P<0.05)。结论:恶性肿瘤组织LRPPRC表达增高;晚期前列腺癌LRPPRC的高表达预示恶性程度高和多发转移。

Objective： To investigate the expressions and clinical significance of LRPPRC in cancer. Methods： Immunohistochemistry was performed to analyze the LRPPRC expression in 120 of gatric cancer tissues？ 80 of cervi-cal cancer tissues and 198 of prostate cancer tissues. The associations between LRPPRC and clinicopathological pa-rameters were analyzed. Results ： Gastric cancer and normal gastric tissues highly expressed LRPPRC in 71. 7% （86/120） and 21. 7% （13/60） of patients, respectively （P〈0 .001 ） ; Cervical cancer and normal cervical tissues highly expressed LRPPRC in 76. 3% （61/80）and 27. 5% （11/40） of patients, respectively （P〈0 .001） ; Prostate cancer and prostate hyperplasia tissues highly expressed LRPPRC in 61. 6% （122/198） and 18. 0% （18/100） of pa-tients ,respectively （P〈0. 001）. A significant associations between the expressions of LRPPRC and Gleason scores （P〈0. 001）,serum PSA levels （P = 0. 002） , serum PSA levels after androgen deprivation therapy （P〈0. 022）and the numbers of metastasis position （P〈0. 001） were observed. Conclusion： There is higher LRPPRC expression in cancer tissues. The high expression of LRPPRC predicted high degree of malignant and more metastasis positions in late stage of prostate cancer patients.