Sirt7在宫颈鳞状细胞癌组织中的表达及意义

Altered Sirt7 expression is associated with cervical squamous cell carcinoma

目的:作为七个Sirtuin(SIRT,又称抗衰老酶)家族成员(Sirt1-Sirt7)之一,Sirt7已被发现在很多肿瘤中异常表达,但其在宫颈癌中的表达仍不清楚。本研究中重点探索Sirt7在宫颈鳞状细胞癌中的表达以及其在宫颈癌发生、发展及转移方面的临床意义。方法:本研究共纳入手术切除宫颈癌组织石蜡标本113例,采用免疫组化(SP)法检测宫颈癌标本39例,宫颈上皮内瘤变标本62例和正常宫颈组织12例中Sirt7的表达情况,并分析Sirt7与宫颈癌临床病理之间的关系。结果:Sirt7在正常宫颈、宫颈鳞状上皮内瘤变(低度)、宫颈鳞状上皮内瘤变(高度)及宫颈鳞癌组织中的阳性表达率依次上升,分别为8.3%,13.1%,41.7%及69.2%(P<0.05)。另外,Sirt7的表达情况与宫颈鳞癌的组织分化程度相关(P<0.05),具有统计学意义,而与临床分期、淋巴结转移及患者年龄无关(P>0.05)。结论:Sirt7可能在宫颈鳞癌的恶性进展中发挥作用,有可能是宫颈鳞癌治疗的一个潜在靶点。

ObjectiveSirt7 is a member of the Sirtuin fami ly,and it has been found abnormal expression in many cancers. However,the clinical significance of Sirt7 expression in cervical squamous cell carcinoma（ SCC） is still un-clear. Methods ： A total of 113 cervical specimens were enrolled in this study. Immunohistochemical expression of Sirt7 was scored and analyzed in normal cervical tissues, cervical squamous intraepithelial lesions and cervical canc-ers,followed by 12 cases,62 cases and 39 cases. The relationship between Sirt7 and clinical and pathological features of cervical carcinoma was also analyzed. Results： The expression of Sirt7 had an ever increasing positive rates from normal cervix to cervical carcinoma,and they were 8. 3% ,1 3 . 1% , 41.1% and 69. 2% , re spectively（ P 〈 0. 05 ） . In addition,Sirt7 expression was associated with high histological grade of cervical cancer, FIGO stage （P 〈 0. 05 ） , which was statistically significant. However,it has nothing to do with the tumor clinical stages,lymph node metastasis and patients, age （P 〉0.05）. Conclusion ： Sirt7 might play a role in the malignant progression of cervical cancer and may be a potential therapeutic target in cervical cancer treatment.