液体活检—通向精准医疗的桥梁

Liquid biopsy technique-the bridge to precision medical

组织活检是癌症的标准诊断程序,然而,由于肿瘤异质性和进化,基于组织活检的癌症诊断在癌症发展、预后的评估中具有局限性。液体活检是检测患者体液中含原发肿瘤生物特性分子的技术,包括循环肿瘤细胞、循环肿瘤DNA和外泌体等的检测。液体活检被广泛的应用于辅助诊断、疗效评价、预测预后、监测复发转移、辅助靶向治疗等方面。本文将对液体活检的生物特性及临床应用进展进行综述。

Tissue biopsy is regarded as the standard diagnostic procedure for cancers. However,tissue biopsy - based cancer diagnostic procedures limits in assessment of cancer development and prognosis as tumor heterogeneity and e-volution. Liquid biopsy represents a technique that detect biological characteristics molecules of the primary tumor in patients,body fluid,such as circulating tumor cells,circulating tumor DNA,and exosomes,etc. Liquid biopsy is widely used as auxiliary diagnosis, efficacy evaluation, predicting prognosis, monitoring recurrence and metastasis, assisting targeted therapy. In this paper,the advancements in biological characteristics and clinical application of liquid biopsy are reviewed.