71例羟基脲不良反应文献分析

Literature Analysis of 71 Cases of Adverse Drug Reactions Induced by Hydroxyurea

目的研究羟基脲致不良反应的规律和特点,为临床合理用药提供参。方法以"羟基脲","不良反应",为检索词,检索中国期刊网全文数据库、维普中文科技期刊全文数据库、万方数据资源,依纳入与排除标准对文献资料进行统计与分析。结果共纳入44篇文献,71例病例,79例次ADR。累及系统器官主要为皮肤及其附件损害、全身性损害及消化系统损害,其中以皮肤及附件损害最为常见,而其中皮肤顽固性溃疡临床表现占比最多。结论重视羟基脲不良反应监测,临床合理使用,警惕该药导致的皮肤顽固性溃疡,确保用药安全。

Objective Through investigating the characteristics and mechanism of adverse drug reactions （ ADRs） induced by carbamazepine, to find its risk factors and provide technical support for safe and rational use of drugs in clinic. Methods Using “ Hydroxyurea”,“adverse reaction” and “ to” as key words to search and retrieve articles in the CNKI,VIP and WanFang Data. According to inclusion and exclusion criteria to analyze the literature. Results A total of 44 papers, 71 cases, 79 series of ADR were included. Systems and organs mainly involved in ADRs were skin and its appendages, systemic damage and digestive system damage. The skin and appendages damage was the most commonly reported ADRs, and refractory skin ulcer accounted for the most. Conclusion It is important to pay attention to the ADR, caused by hydroxyurea, strengthen clinical rational use of drugs, in order to prevent ADR and ensure the safe drug use in clinic.