血清同型半胱氨酸水平与冠心病的相关性分析

Analysis of relationship between serum homocysteine level and coronary heart disease

目的探讨冠心病与血清同型半胱氨酸水平之间的关系。方法选择2014年1月至2016年1月冠心病患者115例为研究对象,其中40例为稳定型心绞痛患者(SAP组),75例为急性冠脉综合征患者(ACS组),再选择同期体检健康者80例作为对照组,分别对其进行D-二聚体(D-DT)、血浆纤维蛋白原(FIB)、血清总胆固醇(TC)、超敏C-反应蛋白(hs-CRP)以及血清同型半胱氨酸(Hcy)检测,对比分析三组的检测结果。结果与对照组相比,ASC组和SAP组Hcy、hs-CRP水平均较高,差异有统计学意义(P<0.05);与对照组和SAP组比较,ACS组D-DT、FIB水平均较高,差异有统计学意义(P<0.05);但是对照组与SAP组血清D-DT、FIB水平比较差异未见统计学意义(P>0.05);与对照组比较,SAP组与ACS组高Hcy血症发生率均较高,差异有统计学意义(P<0.05);同时,经多元Logiatic回归分析,结果显示冠心病患者的血清Hcy水平与D-DT、FIB以及hs-CRP呈正相关(P<0.05)。结论高Hcy血症是诱发冠心病的重要危险因素,及时检测血清Hcy水平,有助于预防和治疗冠心病。

Objective To investigate the relationship between serum homocysteine level and coronary heart disease. Methods One hundred and fifteen patients with coronary heart diseases from January 2014 to January 2016 were selected as the research objects, among which 40 cases of patients were stable angina pectoris （ SAP group）, and 75 cases of patients with acute coronary syndrome （ACS group）, and 80 healthy persons in the same period were selected as the control group. Then, the levels of D-DT, FIB, TC, hs-CRP and Hcy were respectively detected, and the detection results of the three groups were compared and analyzed. Results Compared with the control group, the levels of Hcy and hs-CRP in the ASC group and the SAP group were higher, and the differences were significant （P 〈 0. 05） ; Compared with the control group and the SAP group, the levels of D-DT and FIB in ACS group were higher, and there were significant differences between the two groups （P 〈0. 05） ; But there was no difference in the levels of serum D-DT and FIB between the control group and the SAP group （P 〉 0. 05） ; Compared with the control group, the incidence of high Hcy in SAP group and ACS group were higher, and there were significant differences between the two groups （P 〈 0. 05） ; At the same time, the results showed that the level of serum Hcy was proportional to D-DT, FIB and hs-CRP in patients with coronary heart disease by the multivariate Logiatic regression analysis（P 〈0. 05）. Conclusion The Hcy hyperlipidemia is an important risk factor for coronary heart disease. It is helpful to prevent and treat coronary heart disease by detecting the level of serum Hcy in time.