丹参注射液联合美沙拉嗪治疗溃疡性结肠炎疗效观察

Effect observation of salvia miltiorrhiza combined with mesalazine on ulcerative colitis

目的探讨丹参注射液联合美沙拉嗪治疗溃疡性结肠炎(UC)的疗效。方法选取2013年1月至2016年3月UC患者60例,将其随机分为两组,每组30例。对照组口服美沙拉嗪,观察组加用丹参注射液治疗。比较两组总有效率、Mayo评分、血沉(ESR)、血清C-反应蛋白(CRP)水平。结果观察组总有效率为93.3%(28/30),高于对照组的80.0%(24/30),差异有统计学意义(P<0.05)。治疗后两组患者Mayo评分、ESR、CRP均下降,且观察组低于对照组(P<0.05)。结论丹参注射液联合美沙拉嗪治疗UC能提高临床疗效,减轻炎性反应,值得临床推广。

Objective To investigate the effect of salvia miltiorrhiza combined with mesalazine on ulcerative colitis （UC）. Methods Sixty patients with UC from January 2013 to March 2016 were selected, and were randomly divided into two groups, with 30 cases in each group. The control group was given mesalazine, while the observation group was treated with salvia miltiorrhiza combined with mesalazine. The total effective rate, Mayo score, erythrocyte sedimentation rate（ESR） and C-reactive protein（CRP） were compared between the two groups. Results The total effective rate of the observation group was 93. 3% （28/30）, which was higher than that of the control group[80. 0% （24/30）], the difference was significant （P 〈0. 05）. After treatment, the Mayo score, ESR and CRP in both groups decreased, and which of the observation group were lower than those of the control group （P 〈 0. 05）. Conclusion Combined treatment of salvia miltiorrhiza and mesalazine for UC can significantly increase the curative efficacy and alleviate inflammatory reaction, so it is worthy of clinical application.