危重患儿肠屏障功能障碍时如何进行营养支持

Nutritional support in critically ill children with intestinal barrier dysfunction

肠黏膜屏障损伤是危重患儿常见的病理生理过程，可造成细菌及内毒素移位、肠源性感染，甚至发生多器官功能衰竭。早期诊断肠黏膜屏障损害，积极纠正肠屏障功能障碍，选择适当的营养方式将有助于提高疗效，改善患儿预后。本文就危重患儿肠屏障功能障碍的概念、诊断方法及营养支持的进展等做一阐述。

The injury of the intestinal mucosal barrier is a common pathophysiological process in critically ill children, which can cause translocation of bacteria and endotoxin, enterogenic infection, even multiple organ failure. Early diagnosis of intestinal mucosal barrier damage, positive correction of intestinal dysfunction and appropriate nutritional support can improve the curative effect and prognosis. The concept, diagnosis and nutritional support progress of intestinal barrier dysfunction in critically ill children were reviewed in the paper.