摘要
泛素化在细胞信号通路中是一个重要的转录后修饰过程,参与细胞的增殖、分化、凋亡以及基因表达、信号传递、炎症免疫等生命活动的调控。其中E3泛素连接酶Cbl—b参与T细胞的激活和耐受,与肿瘤免疫也有着密切联系,因而Cbl—b对T细胞的调节及它在肿瘤免疫中的研究具有重要意义。
Ubiquitination represents an important post-transcriptional regulatory mechanism of various cellular pathways,involved in cell proliferation, differentiation, apoptosis, gene expression, signal transmission, inflammation immunity and so on. Cbl-b,which is an E3 ubiquitin-protein ligase,has been demonstrated to play a crucial role in T cell activation ,tolerance and tumor immunity. In this review,we will discuss our current un- derstanding on how Cbl-b regulate activation and tolerance of T cells and its role in tumor immunity.
出处
《国际免疫学杂志》
CAS
2017年第2期193-197,共5页
International Journal of Immunology
基金
国家自然科学基金资助(81172786)
湖北省武汉市青年科技晨光计划资助(201050231077)