盐酸氨溴索雾化吸入联合阿奇霉素静滴对支气管哮喘小儿急性发作期血清IL-10及INF-γ水平的影响

Effect of Aerosol Inhalation of Ambroxol Hydrochloride Combined with Azithromycin on the Serum IL-10 and INF-γ Levels of Children with Acute Onset of Asthma

目的:探讨盐酸氨溴索雾化吸入联合阿奇霉素静滴对支气管哮喘小儿急性发作期血清IL-10及INF-γ水平的影响。方法:收集我院住院治疗的100例小儿支气管哮喘急性发作期患者,随机分为实验组和对照组,每组50例。对照组患者给予阿奇霉素10mg/kg+5%葡萄糖注射液250 mL静脉滴注,1次/d。实验组则在对照组基础上给予盐酸氨溴索3 mg/kg+5 mL生理盐水,使用超声雾化器雾化吸入,15 min/次,3次/d。治疗均5 d为1个疗程,共治疗2个疗程。治疗后,对患者热退时间、咳嗽消失时间、肺部啰音消失时间、白介素-10、干扰素-γ以及临床疗效进行检测并比较。结果:与治疗前相比,两组患者治疗后的血清IL-10、INF-γ水平均升高(P<0.05);与对照组相比,实验组患者IL-10、INF-γ较高,热退时间、咳嗽消失时间、啰音消失时间较短,临床总有效率较高(P<0.05)。两组患者治疗效果相比,实验组(100.0%)的治疗总有效率与对照组(96.0%)相比较高,但差异无统计学意义(P>0.05)。结论:盐酸氨溴索雾化吸入联合阿奇霉素静滴能够提高支气管哮喘小儿急性发作期的临床效果,可能与其升高血清IL-10及INF-γ水平有关。

Objective：To investigate the effect of aerosol inhalation of ambroxol hydrochloride combined with azithromycin on the serum IL-10 and INF-γ levels of children with acute onset of asthma.Methods：100 cases of children with bronchial asthma in our hospital were selected and randomly divided into the experimental group and control group,with 50 cases in each group.The control group was given azithromycin 10 mg ＋ 5% glucose 250 ml by intravenous drip,1 time daily.The experimental group was given ambroxol hydrochloride 3 mg＋5 mL saline group on the basis of control group,using the ultrasonic nebulizer inhalation,15 minutes per time,3 times daily.A total of two courses of treatment with 5 days for each course has been provided.After treatment,the pyretolysis time,disappearance time of cough and pulmonary rales,serum IL-10,interferon gamma levels and clinical curative effect were detected and compared between two groups.Results：The serum IL-10 and INF-γ levels of both groups were increased after treatment than those before treatment（P〈0.05）;compared with the control group,the serum IL-10 and INF-γ levels in the experimental group were higher after treatment（P〈0.05）,the pyretolysis time,disappearance time of cough and pulmonary rales were shorter（P〈0.05）,the total clinical efficacy rate was higher （P〈0.05）.Conclusions：Ambroxol hydrochloride combined with azithromycin atomization inhalation could enhance the clinical effect of acute attack of asthma in children,it might be correlated with the increase of serum IL-10 and INF-γ levels.