双歧杆菌三联活菌片对溃疡性结肠炎患者免疫功能及Fas/FasL表达的影响

Effect of Bifidobacterium Triple Viable Tablets on the Immune Function and Expression of Fas/FasL of Patients with Ulcerative Colitis

目的:研究双歧杆菌三联活菌片对溃疡性结肠炎患者免疫功能及Fas/FasL表达的影响。方法:选取2014年7月至2015年6月本院收治的84例溃疡性结肠炎患者,根据患者入院顺序分为观察组(42例)和对照组(42例)两组。对照组采取美沙拉秦肠溶片进行治疗,观察组在此基础上结合双歧杆菌三联活菌片进行治疗。分析两组患者治疗前和治疗2个月后炎症因子水平、T细胞亚群以及Fas/FasL表达情况,并比较两组患者的临床疗效。结果:观察组总的有效率显著高于对照组(P<0.05)。治疗后,观察组的血清白介素-1(IL-1)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平显著低于对照组(P<0.05),CD4+、CD4+/CD8+T细胞亚群显著高于对照组,CD8+、Fas/FasL表达显著低于对照组,差异均有统计学意义(P<0.05)。结论:使用双歧杆菌三联活菌片治疗溃疡性结肠炎患者能改善患者的免疫功能及Fas/Fasl表达,减轻炎症反应,临床效果良好。

Objective：To study the effect of bifidobacterium triple viable tablets on the immune function and expression of Fas/FasL of patients with ulcerative colitis.Methods：84 patients with ulcerative colitis who were treated from July 2014 to June 2015 in our hospital were selected and divided into the observation group （42 cases） and control group （42 cases） according to the order of admission.The control group was treated with mesalazine enteric-coated tablets,and the observation group was treated with bifidobacterium triple viable tablets.The levels of inflammatory cytokines,T lymphocyte subpopulation and Fas/FasL expression,clinical efficacy were analyzed before and after treatment between two groups.Results：The total efficacy of observation group was significantly higher than that of the control group（P〈0.05）.After treatment,the serum interleukin-1 （1L-1）,interleukin-6（IL-6）,intedeukin-8（IL-8）,tumor necrosis factor-α（TNF-α） levels of observation group were lower than those of the control group（P〈0.05）.The quantity ofCD4＋ and CD4＋/CD8＋ T cells of observation group were significantly higher than those of the control group,The expression of CD8＋ and Fas/FasL were significantly lower than those of the control group（P〈0.05）.Conclusion：Bifidobacterium triple viable tablets could relieve the inflammatory response,improve the immune function and Fas / Fasl expression and had better clinical efficacy.